For research use only. Not for therapeutic Use.
Calpain-2-IN-1 (Formula 1A) is a isoform-specific calpain-2 inhibitor with Kis of 181 nM and 7.8 nM for calpain-1, and calpain-2, respectively. Calpain-2-IN-1 can be used for the research of neurodegenerative diseases and other diseases of synaptic function[1].
| Catalog Number | I044159 |
| CAS Number | 144231-85-6 |
| Synonyms | benzyl N-[(2S)-1-[[(3S)-1-[(3,5-dimethoxyphenyl)methylamino]-1,2-dioxopentan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate |
| Molecular Formula | C28H37N3O7 |
| Purity | ≥95% |
| InChI | InChI=1S/C28H37N3O7/c1-6-23(25(32)27(34)29-16-20-13-21(36-4)15-22(14-20)37-5)30-26(33)24(12-18(2)3)31-28(35)38-17-19-10-8-7-9-11-19/h7-11,13-15,18,23-24H,6,12,16-17H2,1-5H3,(H,29,34)(H,30,33)(H,31,35)/t23-,24-/m0/s1 |
| InChIKey | ZPKXXXUPXHNDFV-ZEQRLZLVSA-N |
| SMILES | CCC(C(=O)C(=O)NCC1=CC(=CC(=C1)OC)OC)NC(=O)C(CC(C)C)NC(=O)OCC2=CC=CC=C2 |
| Reference | [1]. Michel Baudry, et al. Isoform-specific calpain inhibitors, methods of identification, and uses thereof. WO2016077461A2. |
