Calpain Inhibitor Z-LLY-FMK

• CAT Number: I003116
• CAS Number: 133410-84-1
• Molecular Formula: C30H40FN3O6
• Molecular Weight: 557.66
• Purity: ≥95%
• Synonyms: Z-LLY-FMK, Calpain Inhibitor(fluoromethylketone)
• Target: A cathepsin B & L and Calpain inhibitor
• Storage: -20°C
• IUPAC Name: benzyl N-[1-[[1-[[4-fluoro-1-(4-hydroxyphenyl)-3-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
• InChI: InChI=1S/C30H40FN3O6/c1-19(2)14-25(28(37)32-24(27(36)17-31)16-21-10-12-23(35)13-11-21)33-29(38)26(15-20(3)4)34-30(39)40-18-22-8-6-5-7-9-22/h5-13,19-20,24-26,35H,14-18H2,1-4H3,(H,32,37)(H,33,38)(H,34,39)
• InChIKey: JCRSHQCFRMCMOC-UHFFFAOYSA-N
• SMILES: CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)CF)NC(=O)C(CC(C)C)NC(=O)OCC2=CC=CC=C2

Calpain Inhibitor Z-LLY-FMK(CAT: I003116) is a potent and selective irreversible inhibitor of calpains, a family of calcium-dependent cysteine proteases involved in processes such as cytoskeletal remodeling, apoptosis, and signal transduction. The inhibitor covalently binds to the active site of calpains, preventing their proteolytic activity. Z-LLY-FMK is widely used in cell biology and neurodegenerative research to study calpain-mediated pathways and their roles in diseases such as Alzheimer’s disease, Parkinson’s disease, and ischemia-reperfusion injury. Its specificity and stability make it an essential tool for exploring therapeutic strategies targeting calpain activity in pathological conditions involving calcium dysregulation.