For research use only. Not for therapeutic Use.
A potent, cell-permeable, and irreversible inhibitor of calpain II (k₂ = 28,900 M⁻¹s⁻¹). Also acts as an inhibitor of cathepsin L (k₂= 680,000 M⁻¹s⁻¹).
| Catalog Number | I003116 |
| CAS Number | 133410-84-1 |
| Synonyms | Z-LLY-FMK, Calpain Inhibitor(fluoromethylketone) |
| Molecular Formula | C30H40FN3O6 |
| Purity | ≥95% |
| Target | A cathepsin B & L and Calpain inhibitor |
| Storage | -20°C |
| IUPAC Name | benzyl N-[1-[[1-[[4-fluoro-1-(4-hydroxyphenyl)-3-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate |
| InChI | InChI=1S/C30H40FN3O6/c1-19(2)14-25(28(37)32-24(27(36)17-31)16-21-10-12-23(35)13-11-21)33-29(38)26(15-20(3)4)34-30(39)40-18-22-8-6-5-7-9-22/h5-13,19-20,24-26,35H,14-18H2,1-4H3,(H,32,37)(H,33,38)(H,34,39) |
| InChIKey | JCRSHQCFRMCMOC-UHFFFAOYSA-N |
| SMILES | CC(C)CC(C(=O)NC(CC1=CC=C(C=C1)O)C(=O)CF)NC(=O)C(CC(C)C)NC(=O)OCC2=CC=CC=C2 |
