For research use only. Not for therapeutic Use.
Calpeptin（Cat No.:R029868）is a potent, cell-permeable inhibitor of calpains, a family of calcium-dependent cysteine proteases involved in various cellular processes, including apoptosis, cytoskeletal remodeling, and signal transduction. By inhibiting calpains, calpeptin prevents the degradation of key cellular proteins, making it valuable for research into neurodegenerative diseases, cancer, and cardiovascular disorders, where calpain activity is dysregulated. Calpeptin has been shown to reduce cell migration and invasion, offering potential therapeutic applications in cancer metastasis. Its utility in studying calpain-related pathways makes it a critical tool in biochemical and medical research.
| Catalog Number | R029868 |
| CAS Number | 117591-20-5 |
| Synonyms | N-[N-[(Phenylmethoxy)carbonyl]-L-leucyl]-L-norleucinal; [(1S)-1-[[[(1S)-1-Formylpentyl]amino]carbonyl]-3-methylbutyl]carbamic Acid Phenylmethyl Ester;?[S-(R*,R*)]-[1-[[(1-Formylpentyl)amino]carbonyl]-3-methylbutyl]-Carbamic acid, , Phenylmethyl Ester |
| Molecular Formula | C20H30N2O4 |
| Purity | ≥95% |
| Target | Apoptosis |
| Solubility | Soluble in DMSO > 10 mM |
| Storage | Desiccate at 4°C |
| IUPAC Name | benzyl N-[(2S)-4-methyl-1-oxo-1-[[(2S)-1-oxohexan-2-yl]amino]pentan-2-yl]carbamate |
| InChI | InChI=1S/C20H30N2O4/c1-4-5-11-17(13-23)21-19(24)18(12-15(2)3)22-20(25)26-14-16-9-7-6-8-10-16/h6-10,13,15,17-18H,4-5,11-12,14H2,1-3H3,(H,21,24)(H,22,25)/t17-,18-/m0/s1 |
| InChIKey | PGGUOGKHUUUWAF-ROUUACIJSA-N |
| SMILES | CCCC[C@@H](C=O)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1 |
| Reference | </br>1:Calpain inhibitor calpeptin suppresses pancreatic cancer by disrupting cancer-stromal interactions in a mouse xenograft model. Yoshida M, Miyasaka Y, Ohuchida K, Okumura T, Zheng B, Torata N, Fujita H, Nabae T, Manabe T, Shimamoto M, Ohtsuka T, Mizumoto K, Nakamura M.Cancer Sci. 2016 Oct;107(10):1443-1452. doi: 10.1111/cas.13024. Epub 2016 Sep 24. PMID: 27487486 Free PMC Article</br>2:Calpeptin Prevents Malignant Pleural Mesothelioma Cell Proliferation via the Angiopoietin1/Tie2 System. Tabata C, Tabata R, Nakano T.Asian Pac J Cancer Prev. 2016;17(7):3405-9. PMID: 27509983 Free Article</br>3:Neuroprotective Effect of Calpeptin on Acrylamide-Induced Neuropathy in Rats. Wei X, Yan F, E M, Zhang C, Li G, Yang X, Zhang F, Wang S, Yu S.Neurochem Res. 2015 Nov;40(11):2325-32. doi: 10.1007/s11064-015-1722-y. Epub 2015 Sep 30. PMID: 26423962 </br>4:Calpeptin, not calpain, directly inhibits an ion channel of the inner mitochondrial membrane. Derksen M, Vorwerk C, Siemen D.Protoplasma. 2016 May;253(3):835-43. doi: 10.1007/s00709-015-0846-x. Epub 2015 Jun 25. PMID: 26108743 </br>5:[The effect of calpeptin on injury and atrophy of diaphragm under mechanical ventilation in rats]. Shi L, Guo H, Huang J, Ma S, Chen X, Zhu X.Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2014 Aug;26(8):549-53. doi: 10.3760/cma.j.issn.2095-4352.2014.08.005. Chinese. PMID: 25124902 Free Article</br>6:Proteomic study of calpeptin-induced differentiation on calpain-interacting proteins of C2C12 myoblast. Singh NK, Shiwani S, Hwang IH.In Vitro Cell Dev Biol Anim. 2012 Mar;48(3):175-85. doi: 10.1007/s11626-012-9484-1. Epub 2012 Jan 21. PMID: 22271316 </br>7:Calpeptin attenuated apoptosis and intracellular inflammatory changes in muscle cells. Nozaki K, Das A, Ray SK, Banik NL.J Neurosci Res. 2011 Apr;89(4):536-43. doi: 10.1002/jnr.22585. Epub 2011 Feb 2. PMID: 21290412 Free PMC Article</br>8:The calpain inhibitor calpeptin prevents bleomycin-induced pulmonary fibrosis in mice. Tabata C, Tabata R, Nakano T.Clin Exp Immunol. 2010 Dec;162(3):560-7. doi: 10.1111/j.1365-2249.2010.04257.x. Epub 2010 Sep 15. PMID: 20846163 Free PMC Article</br>9:Calpeptin attenuated inflammation, cell death, and axonal damage in animal model of multiple sclerosis. Guyton MK, Das A, Samantaray S, Wallace GC 4th, Butler JT, Ray SK, Banik NL.J Neurosci Res. 2010 Aug 15;88(11):2398-408. doi: 10.1002/jnr.22408. PMID: 20623621 Free PMC Article</br>10:The protective effects and potential mechanism of Calpain inhibitor Calpeptin against focal cerebral ischemia-reperfusion injury in rats. Peng S, Kuang Z, Zhang Y, Xu H, Cheng Q.Mol Biol Rep. 2011 Feb;38(2):905-12. doi: 10.1007/s11033-010-0183-2. Epub 2010 May 16. PMID: 20473717 |
