CAM-IN-1

• CAT Number: I013387
• CAS Number: 251994-14-6
• Molecular Formula: C₁₅H₁₁BrN₂O₂S
• Molecular Weight: 363.23
• Purity: ≥95%
• Target: Others
• Solubility: DMSO
• IUPAC Name: 4-(4-bromophenoxy)-N-methylthieno[2,3-c]pyridine-2-carboxamide
• InChI: InChI=1S/C15H11BrN2O2S/c1-17-15(19)13-6-11-12(7-18-8-14(11)21-13)20-10-4-2-9(16)3-5-10/h2-8H,1H3,(H,17,19)
• InChIKey: OFXAEWYLVPBGGU-UHFFFAOYSA-N
• SMILES: CNC(=O)C1=CC2=C(S1)C=NC=C2OC3=CC=C(C=C3)Br

CAM-IN-1 (Cat.No:I013387) is a potent and selective inhibitor of calmodulin-dependent protein kinase II (CaMKII), with an IC50 value of 0.2 µM. CaMKII plays a crucial role in synaptic plasticity and learning and memory processes. CAM-IN-1 has been shown to prevent the induction of long-term potentiation in hippocampal slices and to impair fear memory consolidation in rats. It is a promising tool for investigating the physiological roles of CaMKII and potential therapeutic applications for neurological disorders.

Reference

[1]. Zhu GD, et al. Selective inhibition of ICAM-1 and E-selectin expression in human endothelial cells. 2. Arylmodifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at C-2 carbamides. J Med Chem. 2001 Oct 11;44(21):3469-87.