CaMKIIα inhibitor compound 4d

• CAT Number: I047692
• CAS Number: 3031484-08-6
• Molecular Formula: C14H11ClO4
• Molecular Weight: 278.69
• Purity: ≥95%
• IUPAC Name: 2-[2-(2-chlorophenoxy)-5-hydroxyphenyl]acetic acid
• InChI: InChI=1S/C14H11ClO4/c15-11-3-1-2-4-13(11)19-12-6-5-10(16)7-9(12)8-14(17)18/h1-7,16H,8H2,(H,17,18)
• SMILES: C1=CC=C(C(=C1)OC2=C(C=C(C=C2)O)CC(=O)O)Cl

CaMKIIα inhibitor compound 4d is a high-affinity ligand with enhanced pharmacokinetic properties interacting strongly with the CaMKII α hub domain (Ki value of 0.027 μM). Powerful tool for potential allosteric regulation of CaMKII α kinase activity.
KEYWORDS: CaMKIIα inhibitor compound 4d | Supplier | CaMKIIα inhibitor | CAS [3031484-08-6] | LCCs | RyRs | PLB | CaMK | Inhibitor | Enzymes | Neurodevelopmental disorde

Reference

Y Tian et al. Discovery and Optimization of 5-Hydroxy-Diclofenac toward a New Class of Ligands with Nanomolar Affinity for the CaMKIIα Hub Domain. J Med Chem. 2022 May 12;65(9):6656-6676.