CaMKII-IN-1

• CAT Number: I000778
• CAS Number: 1208123-85-6
• Molecular Formula: C29H30ClN5O2S
• Molecular Weight: 548.1
• Purity: ≥95%
• Synonyms: N-(6-benzyl-2-(phenethylamino)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl)-3-chloro-2-methylbenzenesulfonamide
• Target: CaM kinase II
• Solubility: DMSO: ≥ 54 mg/mL
• Storage: Store at -20°C
• IC50: 63 nM
• IUPAC Name: N-[6-benzyl-2-(2-phenylethylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]-3-chloro-2-methylbenzenesulfonamide
• InChI: InChI=1S/C29H30ClN5O2S/c1-21-25(30)13-8-14-27(21)38(36,37)34-28-24-20-35(19-23-11-6-3-7-12-23)18-16-26(24)32-29(33-28)31-17-15-22-9-4-2-5-10-22/h2-14H,15-20H2,1H3,(H2,31,32,33,34)
• InChIKey: LGUUETDTMQTHML-UHFFFAOYSA-N
• SMILES: CC1=C(C=CC=C1Cl)S(=O)(=O)NC2=NC(=NC3=C2CN(CC3)CC4=CC=CC=C4)NCCC5=CC=CC=C5

CaMKII-IN-1 (Cat.No:I000778) is a potent and selective inhibitor of CaMKIIα and CaMKIIβ, with IC50 values of 0.63 μM and 0.95 μM, respectively. It can cross the blood-brain barrier and suppresses CaMKII activity in vivo. CaMKII-IN-1 exhibits neuroprotective effects and has potential therapeutic applications for neurological diseases, such as Alzheimer’s disease and schizophrenia.

Reference

[1]. Asano S, et al. 5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidines as novel class of potent and highly selective CaMKII inhibitors. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6696-8.