For research use only. Not for therapeutic Use.
Candesartan is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Candesartan is marketed as the cyclohexyl 1-hydroxyethyl carbonate (cilexetil) ester, known as candesartan cilexetil. Candesartan cilexetil is metabolised completely by esterases in the intestinal wall during absorption to the active candesartan moieity. The use of a prodrug form increases the bioavailability of candesartan. Despite this, absolute bioavailability is relatively poor at 15% (candesartan cilexetil tablets) to 40% (candesartan cilexetil solution). Its IC50 is 15 μg/kg.
Catalog Number | A000781 |
CAS Number | 139481-59-7 |
Synonyms | 139481-59-7; Blopress; Ratacand; 1-((2/’-(1H-Tetrazol-5-yl)-[1,1/’-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid; CV-11974 |
Molecular Formula | C24H20N6O3 |
Purity | ≥95% |
Target | Vitamin D Related/Nuclear Receptor |
Solubility | >14.7mg/mL in DMSO |
Storage | -20°C |
InChI | 1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29) |
InChIKey | HTQMVQVXFRQIKW-UHFFFAOYSA-N |
SMILES | CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O |
Reference | 1: Krishna MV, Sowhardhra M, Kumar MS, Madhavi G, Jadhav T, Thakkar D. Effect of 2: Heck SL, Gulati G, Hoffmann P, von Knobelsdorff-Brenkenhoff F, Storås TH, Ree 3: Murad HA, Gazzaz ZJ, Ali SS, Ibraheem MS. Candesartan, rather than losartan, 4: Amer AM, Allam AN, Abdallah OY. Comparative Pharmaceutical Evaluation of 5: AboulFotouh K, Allam AA, El-Badry M, El-Sayed AM. Development and in vitro/in 6: Bessaguet F, Danigo A, Magy L, Sturtz F, Desmoulière A, Demiot C. Candesartan 7: Lammel-Lindemann JA, Flores-Villalba E, Martagón AJ, DeObeso-Gonzalez E, 8: Lyamin NP, Nalivayeva AV, Mordwintseva AY. [Candesartan is the Basis of 9: Sohn IS, Kim CJ, Ahn T, Youn HJ, Jeon HK, Ihm SH, Cho EJ, Chung WB, Chae SC, 10: Kabel AM, Elkhoely AA. Ameliorative Effect of Coenzyme Q10 and/or Candesartan |