For research use only. Not for therapeutic Use.
Capsazepine (CAT: I001495) is a synthetic compound that acts as a selective antagonist of the transient receptor potential vanilloid 1 (TRPV1) channel. It inhibits the activation of TRPV1, a receptor involved in pain perception and the sensation of heat. Capsazepine blocks the binding of capsaicin, the compound responsible for the hot and spicy sensation of chili peppers, to the TRPV1 channel. It has been used as a pharmacological tool to study the role of TRPV1 in various physiological and pathological processes, including pain, inflammation, and thermoregulation.
| Catalog Number | I001495 |
| CAS Number | 138977-28-3 |
| Synonyms | N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide |
| Molecular Formula | C19H21ClN2O2S |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Solubility | DMSO: ≥ 50 mg/mL |
| Storage | Store at -20°C |
| IC50 | 562 nM (Rat TRPV1) |
| IUPAC Name | N-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide |
| InChI | 1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25) |
| InChIKey | DRCMAZOSEIMCHM-UHFFFAOYSA-N |
| SMILES | C1CC2=CC(=C(C=C2CN(C1)C(=S)NCCC3=CC=C(C=C3)Cl)O)O |
