Captopril

• CAT Number: I004361
• CAS Number: 62571-86-2
• Molecular Formula: C₉H₁₅NO₃S
• Molecular Weight: 217.28
• Purity: ≥95%
• Synonyms: (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid
• Target: RAAS
• Solubility: DMSO 43 mg/mL; Water 2 mg/mL
• Storage: room temp
• InChI: InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
• InChIKey: FAKRSMQSSFJEIM-RQJHMYQMSA-N
• SMILES: CC(CS)C(=O)N1CCCC1C(=O)O

Captopril (Cat No.: I004361) is a groundbreaking angiotensin-converting enzyme inhibitor (ACEI) with a pivotal role in managing hypertension and specific forms of congestive heart failure. It holds a significant place in medical history as the first ACEI drug, marking a therapeutic breakthrough. Captopril’s innovation lies in its novel mechanism of action, which revolutionized the treatment of cardiovascular conditions. By inhibiting ACE, it helps relax blood vessels and reduce blood pressure, offering a more effective approach to managing these conditions.

Reference

1:Laser induced thermal lens microscopy for highly sensitive determination of captopril. Shokoufi N, Abbasi-Ahd A, Kargosha K.Appl Opt. 2017 Apr 10;56(11):E58-E63. doi: 10.1364/AO.56.000E58. PMID: 28414342 2:Captopril does not Potentiate Post-Exercise Hypotension: A Randomized Crossover Study. Queiroz AC, Sousa JC Jr, Silva ND Jr, Tobaldini E, Ortega KC, de Oliveira EM, Brum PC, Montano N, Mion D Jr, Tinucci T, de Moraes Forjaz CL.Int J Sports Med. 2017 Apr;38(4):270-277. doi: 10.1055/s-0042-123044. Epub 2017 Feb 20. PMID: 28219104 3:Captopril apparently increase and cisplatin apparently decrease human albumin concentration in artificial urinary solutions. Kuzioła R, Marczewska B, Marczewski K.J Clin Lab Anal. 2017 Feb 20. doi: 10.1002/jcla.22127. [Epub ahead of print] PMID: 28217897 4:Effect of captopril on radiation-induced TGF-β1 secretion in EA.Hy926 human umbilical vein endothelial cells. Wei J, Xu H, Liu Y, Li B, Zhou F.Oncotarget. 2017 Mar 28;8(13):20842-20850. doi: 10.18632/oncotarget.15356. PMID: 28209920 Free PMC Article5:Effect of ivabradine, captopril and melatonin on the behaviour of rats in L-nitro-arginine methyl ester-induced hypertension. Aziriova S, Repova K, Krajcirovicova K, Baka T, Zorad S, Mojto V, Slavkovsky P, Hodosy J, Adamcova M, Paulis L, Simko F.J Physiol Pharmacol. 2016 Dec;67(6):895-902. PMID: 28195070 Free Article6:Correction: Atorvastatin, Losartan and Captopril Lead to Upregulation of TGF-β, and Downregulation of IL-6 in Coronary Artery Disease and Hypertension. Sepehri Z, Masoumi M, Ebrahimi N, Kiani Z, Nasiri AA, Kohan F, Fathollahi MS, Arababadi MK, Asadikaram G.PLoS One. 2017 Feb 13;12(2):e0172404. doi: 10.1371/journal.pone.0172404. eCollection 2017. PMID: 28192516 Free PMC Article7:Amplified nanostructure electrochemical sensor for simultaneous determination of captopril, acetaminophen, tyrosine and hydrochlorothiazide. Karimi-Maleh H, Ganjali MR, Norouzi P, Bananezhad A.Mater Sci Eng C Mater Biol Appl. 2017 Apr 1;73:472-477. doi: 10.1016/j.msec.2016.12.094. Epub 2016 Dec 21. PMID: 28183634 8:Preservation of vascular DDAH activity contributes to the protection of captopril against endothelial dysfunction in hyperlipidemic rabbits. Lin Y, Feng M, Lu CW, Lei YP, He ZM, Xiong Y.Eur J Pharmacol. 2017 Mar 5;798:43-48. doi: 10.1016/j.ejphar.2017.01.041. Epub 2017 Feb 3. PMID: 28163022 9:The effect of captopril on the performance of the control strategies of BJUT-II VAD. Gu K, Gao B, Chang Y, Zeng Y.Biomed Eng Online. 2016 Dec 28;15(Suppl 2):123. doi: 10.1186/s12938-016-0247-1. PMID: 28155689 Free PMC Article10:Differential response of bone and kidney to ACEI in db/db mice: A potential effect of captopril on accelerating bone loss. Zhang Y, Li XL, Sha NN, Shu B, Zhao YJ, Wang XL, Xiao HH, Shi Q, Wong MS, Wang YJ.Bone. 2017 Apr;97:222-232. doi: 10.1016/j.bone.2017.01.029. Epub 2017 Jan 24. PMID: 28130181