For research use only. Not for therapeutic Use.
Carbamazepine is a medication used primarily in the treatment of epilepsy and neuropathic pain. For seizures it works as well as phenytoin and valproate. It is not effective for absence seizures or myoclonic seizures. It may be used in schizophrenia along with other medications and as a second line agent in bipolar disorder. It is taken two to four times per day. A controlled release formulation is available for which there is tentative evidence showing less side effects.
| Catalog Number | A001114 |
| CAS Number | 298-46-4 |
| Synonyms | NSC 169864 |
| Molecular Formula | C15H12N2O |
| Purity | ≥95% |
| Target | Sodium Channel |
| Solubility | >10.9mg/mL in DMSO |
| Storage | 3 years -20C powder |
| Reference | </br>1:Carbamazepine Therapy and <i>HLA</i> Genotypes. Dean L.In: Pratt V, McLeod H, Dean L, Malheiro A, Rubinstein W, editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012-.2015 Oct 14. PMID: 28520367 Free Books & Documents</br>2:Extensive transformation of the pharmaceutical carbamazepine following uptake into intact tomato plants. Riemenschneider C, Seiwert B, Moeder M, Schwarz D, Reemtsma T.Environ Sci Technol. 2017 May 15. doi: 10.1021/acs.est.6b06485. [Epub ahead of print] PMID: 28506063 </br>3:Interference-free Determination of Carbamazepine in Human Serum Using High Performance Liquid Chromatography: A Comprehensive Research with Three-way Calibration Methods. Ghafghazi S, Moini Zanjani T, Vosough M, Sabetkasaei M.Iran J Pharm Res. 2017 Winter;16(1):120-131. PMID: 28496467 Free PMC Article</br>4:Evaluation of a biphasic in vitro dissolution test for estimating the bioavailability of carbamazepine polymorphic forms. Deng J, Staufenbiel S, Bodmeier R.Eur J Pharm Sci. 2017 May 6;105:64-70. doi: 10.1016/j.ejps.2017.05.013. [Epub ahead of print] PMID: 28487146 </br>5:/Late/ Withdrawal Syndrome after Carbamazepine <i>In Utero</i> Exposure in a CYP2C9 Slow Metabolizer Newborn. Passia E, Rock N, Pfister RE, Ing Lorenzini KR, Desmeules J, Samer CF.Front Pharmacol. 2017 Apr 21;8:217. doi: 10.3389/fphar.2017.00217. eCollection 2017. PMID: 28484392 Free PMC Article</br>6:Photodegradation of carbamazepine with BiOCl/Fe<sub>3</sub>O<sub>4</sub> catalyst under simulated solar light irradiation. Chen H, Wang X, Bi W, Wu Y, Dong W.J Colloid Interface Sci. 2017 Apr 12;502:89-99. doi: 10.1016/j.jcis.2017.04.031. [Epub ahead of print] PMID: 28478225 </br>7:Photochemically Induced Bound Residue Formation of Carbamazepine with Dissolved Organic Matter. Raeke J, Lechtenfeld OJ, Seiwert B, Meier T, Riemenschneider C, Reemtsma T.Environ Sci Technol. 2017 May 16;51(10):5523-5530. doi: 10.1021/acs.est.7b00823. Epub 2017 May 5. PMID: 28474521 </br>8:Stevens-Johnson Syndrome following Failure of Genetic Screening prior to Carbamazepine Prescription. Nasir SA, Tan HL, Tan HJ, Hussaini HM, Ramli R.Case Rep Dent. 2017;2017:4201357. doi: 10.1155/2017/4201357. Epub 2017 Apr 3. PMID: 28473929 Free PMC Article</br>9:Activity clamp provides insights into paradoxical effects of the anti-seizure drug carbamazepine. Morris G, Leite M, Kullmann DM, Pavlov I, Schorge S, Lignani G.J Neurosci. 2017 May 4. pii: 3697-16. doi: 10.1523/JNEUROSCI.3697-16.2017. [Epub ahead of print] PMID: 28473648 </br>10:External quality assessment for laboratory testing of HLA-B*15:02 allele in relation to carbamazepine therapy. Lin G, Zhang K, Han Y, Xie J, Li J.J Clin Lab Anal. 2017 Apr 25. doi: 10.1002/jcla.22242. [Epub ahead of print] PMID: 28440597 |
