For research use only. Not for therapeutic Use.
Carbazochrome, also known as Adona and AC-17, is a hemostatic which increases capillary resistance and activates platelet factors.
| Catalog Number | R045666 |
| CAS Number | 69-81-8 |
| Synonyms | 2-(1,2,3,6-Tetrahydro-3-hydroxy-1-methyl-6-oxo-5H-indol-5-ylidene)hydrazinecarboxamide; 3-Hydroxy-1-methyl-5,6-indolinedione 5-Semicarbazone; Adrenochrome Semicarbazone; Adchnon; Adedolon; Adrenochrome Monosemicarbazone; Adrenostazin; Adrenoxyl; Adre |
| Molecular Formula | C₁₀H₁₂N₄O₃ |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | -20°C |
| Reference | </br>1:An old drug for a new application: carbazochrome-sodium-sulfonate in HHT. Passali GC, De Corso E, Bastanza G, Di Gennaro L; HHT Gemelli Study Group..J Clin Pharmacol. 2015 May;55(5):601-2. doi: 10.1002/jcph.452. Epub 2015 Jan 16. No abstract available. PMID: 25644784 </br>2:Validated spectrophotometric methods for simultaneous determination of troxerutin and carbazochrome in dosage form. Khattab FI, Ramadan NK, Hegazy MA, Al-Ghobashy MA, Ghoniem NS.Spectrochim Acta A Mol Biomol Spectrosc. 2015 Mar 15;139:206-13. doi: 10.1016/j.saa.2014.12.047. Epub 2014 Dec 24. PMID: 25561299 </br>3:Effect of carbazochrome sodium sulfonate on refractory chronic prostatitis. Oh-oka H, Yamada T, Noto H, Umeyama T, Kadekawa K, Ashitomi K, Nishijima S, Sugaya K.Int J Urol. 2014 Nov;21(11):1162-6. doi: 10.1111/iju.12533. Epub 2014 Jun 25. PMID: 24964194 Free Article</br>4:Optimization of solid phase extraction clean up and validation of quantitative determination of carbazochrome sodium sulfonate in human plasma by liquid chromatography-electrospray ionization tandem mass spectrometry. Hu X, Zheng Y, Wu G, Liu J, Zhu M, Zhou H, Zhai Y, Wu L, Shen-Tu J.J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 1;951-952:1-6. doi: 10.1016/j.jchromb.2014.01.014. Epub 2014 Jan 15. PMID: 24487058 </br>5:Determination of carbazochrome by fluorescence quenching method. Gan X, Liu S, Liu Z, Hu X, Cui Z, Wang Y.Spectrochim Acta A Mol Biomol Spectrosc. 2012 Nov;97:161-6. doi: 10.1016/j.saa.2012.05.062. Epub 2012 Jun 12. PMID: 22750685 </br>6:Fluorescence quenching method for the determination of carbazochrome sodium sulfonate with aromatic amino acids. Gan XJ, Liu SP, Liu ZF, Hu XL, Tian J, Xue JX.Luminescence. 2013 May-Jun;28(3):265-9. doi: 10.1002/bio.2375. Epub 2012 Apr 30. PMID: 22544487 </br>7:Risk of deep venous thrombosis in drain clamping with tranexamic acid and carbazochrome sodium sulfonate hydrate in total knee arthroplasty. Onodera T, Majima T, Sawaguchi N, Kasahara Y, Ishigaki T, Minami A.J Arthroplasty. 2012 Jan;27(1):105-8. doi: 10.1016/j.arth.2011.02.004. Epub 2011 Mar 23. PMID: 21435821 </br>8:Development and validation of a robust LC-MS-MS with atmospheric pressure chemical ionization for quantitation of carbazochrome sodium sulfonate in human plasma: application to a pharmacokinetic study. Song M, Zhao H, Wang L, Yang L, Hang T, Wen A.Biomed Chromatogr. 2010 Sep;24(9):990-9. doi: 10.1002/bmc.1397. PMID: 20146401 </br>9:Effect of furosemide and furosemide-carbazochrome combination on exercise-induced pulmonary hemorrhage in Standardbred racehorses. Perez-Moreno CI, Couëtil LL, Pratt SM, Ochoa-Acuña HG, Raskin RE, Russell MA.Can Vet J. 2009 Aug;50(8):821-7. PMID: 19881919 Free PMC Article</br>10:Carbazochrome sodium sulfonate (AC-17) reverses endothelial barrier dysfunction through inhibition of phosphatidylinositol hydrolysis in cultured porcine endothelial cells. Sendo T, Itoh Y, Aki K, Oka M, Oishi R.Naunyn Schmiedebergs Arch Pharmacol. 2003 Sep;368(3):175-80. Epub 2003 Aug 20. PMID: 12928765 |
