Carbenicillin disodium

• CAT Number: A001178
• CAS Number: 4800-94-6
• Molecular Formula: C17H16N2O6SNa2
• Molecular Weight: 422.40
• Purity: ≥95%
• Synonyms: BRL-2064
• Target: Antibiotic
• Solubility: >21.45mg/mL in DMSO
• Storage: 3 years -20C powder
• IUPAC Name: disodium;(2S,5R,6R)-6-[(2-carboxylato-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
• InChI: InChI=1S/C17H18N2O6S.2Na/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8;;/h3-7,9-11,14H,1-2H3,(H,18,20)(H,22,23)(H,24,25);;/q;2*+1/p-2/t9?,10-,11+,14-;;/m1../s1
• InChIKey: RTYJTGSCYUUYAL-YCAHSCEMSA-L
• SMILES: CC1([C@@H](N2[C@H](S1)[C@@H](C2=O)NC(=O)C(C3=CC=CC=C3)C(=O)[O-])C(=O)[O-])C.[Na+].[Na+]

Carbenicillin Disodium（Cat No.:A001178）is a broad-spectrum, beta-lactam antibiotic from the penicillin class, primarily effective against Gram-negative bacteria, including Pseudomonas aeruginosa and Proteus species. It inhibits bacterial cell wall synthesis, leading to cell lysis and death. Carbenicillin Disodium is frequently used in laboratory settings for bacterial selection in cloning experiments, especially in recombinant DNA technology, as it allows for the selection of carbenicillin-resistant cells. In clinical applications, it treats urinary tract, respiratory, and systemic infections, although its use has declined due to the availability of newer antibiotics.

Reference

Guzmán, Flavio, MD. /Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.E. Bourhis, S. G. Hymowitz and A. G. Cochran 2007. The mitotic regulator Survivin binds as a monomer to its functional interactor BorealinMatsuda N., Isuzugawa K., Gao M., Takshina T. and Nishimura, K. Development of Agrobacterium-mediated transformation system in pear cultivars with low-regeneration Frequency. Hortscience, Vol. 39(4), July 2004