Carbenoxolone Disodium

• CAT Number: R010219
• CAS Number: 7421-40-1
• Molecular Formula: C34H48O7 • 2Na
• Molecular Weight: 614.7
• Purity: ≥95%
• Synonyms: (3β,20β)-3-(3-Carboxy-1-oxopropoxy)-11-oxo-olean-12-en-29-oic Acid;?3β-Hydroxy-11-oxoolean-12-en-30-oic Acid Hydrogen Succinate Disodium Salt; Carbenoxalone Sodium; Bioral; Neogel; Pyrogastrone; Sanodin
• Target: Gap Junction
• Solubility: Soluble to 100 mM in sterile water
• Storage: Store at -20C
• InChIKey: BQENDLAVTKRQMS-SBBGFIFASA-L

Carbenoxolone disodium(CAT: R010219) is a disodium salt of carbenoxolone, a synthetic derivative of glycyrrhetinic acid found in licorice root. Its mode of action involves inhibiting the enzyme 11β-hydroxysteroid dehydrogenase, leading to decreased conversion of cortisone to cortisol and consequently influencing glucocorticoid activity. Pharmacologically, carbenoxolone disodium exhibits anti-inflammatory and anti-ulcer properties, with applications in the treatment of various gastrointestinal disorders, including peptic ulcers. Research continues to explore its therapeutic potential while addressing safety considerations, emphasizing its role in understanding glucocorticoid regulation and its applications in certain gastrointestinal conditions.