Carbidopa hydrate

• CAT Number: I009625
• CAS Number: 38821-49-7
• Molecular Formula: C10H16N2O5
• Molecular Weight: 244.24
• Purity: ≥95%
• Synonyms: Carbidopa; Carbidopa hydrate; Lodosyn;3-(3,4-dihydroxyphenyl)-2-hydrazineyl-2-methylpropanoic acid hydrate
• Target: Aryl Hydrocarbon Receptor
• Solubility: Soluble in DMSO
• Storage: Store at 0-8 °C
• InChI: InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2
• InChIKey: QTAOMKOIBXZKND-UHFFFAOYSA-N
• SMILES: O=C(O)C(C)(NN)CC1=CC=C(O)C(O)=C1.[H]O[H]

Carbidopa hydrate (Cat No.: I009625) is a peripheral decarboxylase inhibitor primarily used in combination with levodopa for Parkinson’s disease treatment. By preventing the peripheral conversion of levodopa to dopamine, it enhances levodopa’s availability in the brain while reducing side effects like nausea. Carbidopa itself does not cross the blood-brain barrier, ensuring dopamine synthesis occurs centrally. This hydrate form improves stability and solubility. It is also used in research for neurodegenerative disorders and metabolic studies involving aromatic amino acid decarboxylation.

Reference

1: Polonini HC, Silva SL, Cunha CN, Brandão MA, Ferreira AO. Compatibility of cholecalciferol, haloperidol, imipramine hydrochloride, levodopa/carbidopa, lorazepam, minocycline hydrochloride, tacrolimus monohydrate, terbinafine, tramadol hydrochloride and valsartan in SyrSpend SF PH4 oral suspensions. Pharmazie. 2016 Apr;71(4):185-91. PubMed PMID: 27209697.2: Vickers S, Stuart EK, Hucker HB. Further studies on the metabolism of carbidopa, (minus)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate, in the human, Rhesus monkey, dog, and rat. J Med Chem. 1975 Feb;18(2):134-8. PubMed PMID: 804550.3: Vickers S, Stuart EK, Bianchine JR, Hucker HB, Jaffe ME, Rhodes RE, Vandenheuvel WJ. Metabolism of carbidopa (1-(-)-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate), an aromatic amino acid decarboxylase inhibitor, in the rat, rhesus monkey, and man. Drug Metab Dispos. 1974 Jan-Feb;2(1):9-22. PubMed PMID: 4150141.4: Scriabine A, Ludden CT, Stone CA, Wurtman RJ, Watkins CJ. Enhancement of the anti-hypertensive effect of methyldopa and other anti-hypertensive drugs by carbidopa in spontaneously hypertensive rats. Clin Sci Mol Med Suppl. 1976 Dec;3:407s-410s. PubMed PMID: 1071655.5: Fraenkel G, Blechl A, Blechl J, Herman P, Seligman MI. 3/’:5/’-cyclic AMP and hormonal control of puparium formation in the fleshfly Sarcophaga bullata. Proc Natl Acad Sci U S A. 1977 May;74(5):2182-6. PubMed PMID: 194250; PubMed Central PMCID: PMC431100.6: Bayes M, Rabasseda X, Prous JR. Gateways to Clinical Trials. June 2002. Methods Find Exp Clin Pharmacol. 2002 Jun;24(5):291-327. Review. PubMed PMID: 12168506.7: Itskovitz HD, Chen YH, Stier CT Jr. Reciprocal renal effects of dopamine and 5-hydroxytryptamine formed within the rat kidney. Clin Sci (Lond). 1988 Nov;75(5):503-7. PubMed PMID: 3151164.8: Smith SA, Pogson CL. Tryptophan and the control of plasma glucose concentrations in the rat. Biochem J. 1977 Dec 15;168(3):495-506. PubMed PMID: 147076; PubMed Central PMCID: PMC1183797.