For research use only. Not for therapeutic Use.
Carbidopa is an L-amino acid decarboxylase inhibitor. It inhibits formation of dopamine granules and inhibits restoration of norepinephrine and other catecholamine production in models with mutant isoforms of dopamine β-hydroxylase.
| Catalog Number | I009625 |
| CAS Number | 38821-49-7 |
| Synonyms | Carbidopa; Carbidopa hydrate; Lodosyn;3-(3,4-dihydroxyphenyl)-2-hydrazineyl-2-methylpropanoic acid hydrate |
| Molecular Formula | C10H16N2O5 |
| Purity | ≥95% |
| Target | L-amino acid decarboxylase inhibitor |
| Solubility | Soluble in DMSO |
| Storage | Store at 0-8 °C |
| InChI | InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2 |
| InChIKey | QTAOMKOIBXZKND-UHFFFAOYSA-N |
| SMILES | O=C(O)C(C)(NN)CC1=CC=C(O)C(O)=C1.[H]O[H] |
| Reference | </br>1: Polonini HC, Silva SL, Cunha CN, Brandão MA, Ferreira AO. Compatibility of cholecalciferol, haloperidol, imipramine hydrochloride, levodopa/carbidopa, lorazepam, minocycline hydrochloride, tacrolimus monohydrate, terbinafine, tramadol hydrochloride and valsartan in SyrSpend SF PH4 oral suspensions. Pharmazie. 2016 Apr;71(4):185-91. PubMed PMID: 27209697.</br>2: Vickers S, Stuart EK, Hucker HB. Further studies on the metabolism of carbidopa, (minus)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate, in the human, Rhesus monkey, dog, and rat. J Med Chem. 1975 Feb;18(2):134-8. PubMed PMID: 804550.</br>3: Vickers S, Stuart EK, Bianchine JR, Hucker HB, Jaffe ME, Rhodes RE, Vandenheuvel WJ. Metabolism of carbidopa (1-(-)-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate), an aromatic amino acid decarboxylase inhibitor, in the rat, rhesus monkey, and man. Drug Metab Dispos. 1974 Jan-Feb;2(1):9-22. PubMed PMID: 4150141.</br>4: Scriabine A, Ludden CT, Stone CA, Wurtman RJ, Watkins CJ. Enhancement of the anti-hypertensive effect of methyldopa and other anti-hypertensive drugs by carbidopa in spontaneously hypertensive rats. Clin Sci Mol Med Suppl. 1976 Dec;3:407s-410s. PubMed PMID: 1071655.</br>5: Fraenkel G, Blechl A, Blechl J, Herman P, Seligman MI. 3/’:5/’-cyclic AMP and hormonal control of puparium formation in the fleshfly Sarcophaga bullata. Proc Natl Acad Sci U S A. 1977 May;74(5):2182-6. PubMed PMID: 194250; PubMed Central PMCID: PMC431100.</br>6: Bayes M, Rabasseda X, Prous JR. Gateways to Clinical Trials. June 2002. Methods Find Exp Clin Pharmacol. 2002 Jun;24(5):291-327. Review. PubMed PMID: 12168506.</br>7: Itskovitz HD, Chen YH, Stier CT Jr. Reciprocal renal effects of dopamine and 5-hydroxytryptamine formed within the rat kidney. Clin Sci (Lond). 1988 Nov;75(5):503-7. PubMed PMID: 3151164.</br>8: Smith SA, Pogson CL. Tryptophan and the control of plasma glucose concentrations in the rat. Biochem J. 1977 Dec 15;168(3):495-506. PubMed PMID: 147076; PubMed Central PMCID: PMC1183797.</br></br> |
