For research use only. Not for therapeutic Use.
Carboplatin(Cat No.:A001041)is a platinum-based chemotherapy drug used to treat various cancers, including ovarian, lung, bladder, and testicular cancers. It works by forming DNA cross-links, disrupting the DNA structure and preventing cancer cells from dividing and replicating. Carboplatin is often preferred over cisplatin due to its reduced toxicity profile, particularly concerning nephrotoxicity and nausea. However, it can still cause side effects such as myelosuppression, peripheral neuropathy, and hypersensitivity reactions. Carboplatin is frequently used in combination with other chemotherapy agents to enhance its effectiveness and improve treatment outcomes for patients.
Catalog Number | A001041 |
CAS Number | 41575-94-4 |
Synonyms | JM-8, CBDCA, NSC 241240; Carboplatinum; 41575-94-4; Cbdca; Paraplatin; Carbopaltin |
Molecular Formula | C6H12N2O4Pt |
Purity | ≥95% |
Target | DNA Synthesis |
Solubility | Limited solubility |
Storage | -20°C |
IUPAC Name | azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) |
InChI | InChI=1S/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H2;/q;2*-1;+2 |
InChIKey | VSRXQHXAPYXROS-UHFFFAOYSA-N |
SMILES | C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2] |
Reference | 1: Ito M, Horita N, Nagashima A, Kaneko T. Carboplatin plus pemetrexed for the 2: Wang L, Syn NL, Subhash VV, Any Y, Thuya WL, Cheow E, Kong L, Yu F, Peethala 3: Snee M. Quality of life comparing carboplatin with cisplatin in the treatment 4: Dunn LA, Fury MG, Xiao H, Baxi SS, Sherman EJ, Korte S, Pfister C, Haque S, 5: Furubayashi N, Negishi T, Yamashita T, Kusano S, Taguchi K, Shimokawa M, 6: Bouman-Wammes EW, van den Berg HP, de Munck L, Beeker A, Smorenburg CH, 7: Chen X, Wang J, Fu Z, Zhu B, Wang J, Guan S, Hua Z. Curcumin activates DNA 8: Zhu T, Xu F, Zhang L, Zhang Y, Yang C, Cheng M, Chen F, Wang K. Measurement of 9: Gnekow AK, Walker DA, Kandels D, Picton S, Giorgio Perilongo, Grill J, 10: Huang L, Liu Q, Chen S, Shao Z. Cisplatin versus carboplatin in combination |