Carboxypeptidase G2 (CPG2) Inhibitor

• CAT Number: I002462
• CAS Number: 192203-60-4
• Molecular Formula: C13H15NO6S
• Molecular Weight: 313.33
• Purity: ≥95%
• Synonyms: (2S)-2-[(4-methoxyphenyl)sulfanylcarbonylamino]pentanedioic acid
• Target: Carboxypeptidase
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• InChI: InChI=1S/C13H15NO6S/c1-20-8-2-4-9(5-3-8)21-13(19)14-10(12(17)18)6-7-11(15)16/h2-5,10H,6-7H2,1H3,(H,14,19)(H,15,16)(H,17,18)/t10-/m0/s1
• InChIKey: OBCGYIKABKFIQB-JTQLQIEISA-N
• SMILES: COC1=CC=C(C=C1)SC(=O)N[C@@H](CCC(=O)O)C(=O)O

Carboxypeptidase G2 (CPG2) inhibitors（Cat No.:I002462）are compounds designed to block the activity of CPG2, an enzyme that plays a role in the hydrolysis of folate analogs, such as methotrexate. CPG2 is used therapeutically in certain treatments to clear toxic folate analogs from the body, especially in cases of overdose or toxicity. Inhibiting CPG2 can potentially enhance the efficacy of folate-based drugs by preventing their breakdown, making CPG2 inhibitors useful in drug development strategies aimed at improving the pharmacokinetics of chemotherapy agents. Research continues to explore the application of CPG2 inhibitors in optimizing cancer treatments and reducing toxicity.