Cardiogenol C (hydrochloride)

• CAT Number: R064361
• CAS Number: 671225-39-1
• Molecular Formula: C13H16N4O2 • HCl
• Molecular Weight: 296.8
• Purity: ≥95%
• Synonyms: 2-[[2-[(4-methoxyphenyl)amino]-4-pyrimidinyl]amino]-ethanol
• Target: β-catenin
• Storage: -20°C
• InChI: InChI=1S/C13H16N4O2.ClH/c1-19-11-4-2-10(3-5-11)16-13-15-7-6-12(17-13)14-8-9-18;/h2-7,18H,8-9H2,1H3,(H2,14,15,16,17);1H
• InChIKey: QQAHYSZVJLHCNA-UHFFFAOYSA-N
• SMILES: COC1=CC=C(NC2=NC(NCCO)=CC=N2)C=C1.Cl

Most tissues have an endogenous pool of progenitor cells to draw from upon injury. The adult heart, however, contains a limited number of undifferentiated cells and techniques to replicate these cells from other pluripotent tissues have thus far been nonselective and inefficient. Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC-<wbr></wbr> (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 µM. About 90% of embryonic stem cells treated with 0.25 µM cardiogenol C express the cardiac muscle cell specific transcription factors GATA-<wbr></wbr>4, MEF2, and Nkx2.5 and display the characteristic beating behavior of differentiated cardiomyocytes.

Reference

1.Wu, X.,Ding, S.,Ding, Q., et al. Small molecules that induce cardiomyogenesis in embryonic stem cells. Journal of the American Chemical Society 126(6), 1590-1591 (2004).