CARDIOTOXIN

• CAT Number: P000020
• CAS Number: 56574-47-1
• Molecular Formula: C19H28F6NO5PS
• Purity: ≥95%
• Solubility: Well in water and saline
• Storage: Stable in freeze-dried stateIn solution, keep at -20 °C

CARDIOTOXIN(cas 56574-47-1) is a protein kinase C specific inhibitor with an IC50 of 1-3 μM. It depolarizes cardiomyocytes. It has also lytic activity on other cells like red blood cells.


60-amino acid peptide with 4 disulfide bridges<!—->, from Naja pallida snake venom.

It interacts with sulfatides in the cell membrane. This induces pore formation and cell internalization responsible for cytotoxicity in cardiomyocytes. It has also an action on mitochondrial mambrane which leads to swelling and fragmentation.

Reference

– Chiou et al., /Cobra venom cardiotoxin (cytotoxin) isoforms and neurotoxin: comparative potency of protein kinase C inhibition and cancer cell cytotoxicity and mode of enzyme inhibition./ Biochemistry 1993 32(8):2062-2067

– Fletcher et al., /Possible mechanisms of Action of cobra snake venom cardiotoxins and bee venom melittin./ Toxicon 1993 31(6):669-695

– Raynor et al., /Membrane interactions of amphiphilic polypeptides mastoparan, melittin, polymyxin B, and cardiotoxin./ J. Biol. Chem. 1991 266(5): 2753-2758

– D/’Albis et al., /Regeneration after cardiotoxin injury of innervated and denervated slow and fast muscles of mammals./ Eur. J. Biochem. 1988 174:103-110

– Grognet et al., Molecular Immunology 1986 23(12):1329-1337

– Fryklund et al., Biochemistry 1975 14:2865