For research use only. Not for therapeutic Use.
Carisbamate (RWJ-333369) is an orally active neuromodulator. Carisbamate prevents the development and production of epilep-like discharges and has a neuroprotective effect after in vitro epilepticus-like injury. Carisbamate has good antiepileptic activity in genetic models of generalized and nonconvulsive epilepsy[1][2][3].
Carisbamate (200 µM; 12 h) exhibits antiepileptic effects on SREDs model of hippocampal cells[1].
Carisbamate (200 µM; 24 h) shows long lasting effects on the hippocampal neurons that are independent from antiepileptic effects in vitro[1].
Carisbamate not only inhibits the development and expression of SREDs in the majority of neurons, but also decreases seizure frequency and duration in the few neurons that still has an occasional epileptiform event[1].
Carisbamate (200 µM) shows neuroprotective effects on hippocampal cells with SE (status epilepticus)-like injury[1].
Carisbamate (10, 30, 60 mg/kg; i.p.; single) dose dependently reduces the expression of spike-and-wave discharges (SWD) in absence seizures rat model[2].
Carisbamate (20, 30 mg/kg; i.p.; single) shows no wild running episode or tonic seizure occurres in any of the rats tested[2].
| Catalog Number | R013510 |
| CAS Number | 194085-75-1 |
| Synonyms | [(2S)-2-(2-chlorophenyl)-2-hydroxyethyl] carbamate |
| Molecular Formula | C9H10ClNO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C9H10ClNO3/c10-7-4-2-1-3-6(7)8(12)5-14-9(11)13/h1-4,8,12H,5H2,(H2,11,13)/t8-/m1/s1 |
| InChIKey | OLBWFRRUHYQABZ-MRVPVSSYSA-N |
| SMILES | C1=CC=C(C(=C1)C(COC(=O)N)O)Cl |
| Reference | [1]. Deshpande LS, et al. Carisbamate prevents the development and expression of spontaneous recurrent epileptiform discharges and is neuroprotective in cultured hippocampal neurons. Epilepsia. 2008 Oct;49(10):1795-802. [2]. François J, et al. Effects of carisbamate (RWJ-333369) in two models of genetically determined generalized epilepsy, the GAERS and the audiogenic Wistar AS. Epilepsia. 2008 Mar;49(3):393-9. [3]. Novak GP, et al. Carisbamate (RWJ-333369). Neurotherapeutics. 2007 Jan;4(1):106-9. |
