CARM1-IN-3

• CAT Number: I040934
• CAS Number: 912970-67-3
• Molecular Formula: C24H32N4O2
• Molecular Weight: 408.54
• Purity: ≥95%
• Synonyms: 2-[4-[2-(2,6-dimethoxyphenyl)-7-methyl-3H-benzimidazol-5-yl]piperidin-1-yl]-N-methylethanamine
• InChI: InChI=1S/C24H32N4O2/c1-16-14-18(17-8-11-28(12-9-17)13-10-25-2)15-19-23(16)27-24(26-19)22-20(29-3)6-5-7-21(22)30-4/h5-7,14-15,17,25H,8-13H2,1-4H3,(H,26,27)
• InChIKey: PFOQIHIIOLBCEQ-UHFFFAOYSA-N
• SMILES: CC1=CC(=CC2=C1N=C(N2)C3=C(C=CC=C3OC)OC)C4CCN(CC4)CCNC

CARM1-IN-3 (compound 17b) is a potent and selective co-activator associated arginine methyltransferase (CARM1) inhibitor with IC50 values of 0.07, >25 µM for CARM1 and CARM3, respectively[1].

Reference

[1]. Wan H, et al. Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)–Hit to Lead studies. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5063-6.
 [Content Brief]