For research use only. Not for therapeutic Use.
Carmustine (CAT: I001956) is a potent alkylating antineoplastic agent that exhibits cell-cycle phase nonspecific activity. It belongs to the nitrosourea class of chemotherapeutic drugs and functions by alkylating DNA, leading to the formation of interstrand and intrastrand cross-links. These DNA cross-links disrupt the replication and transcription processes, ultimately inducing DNA damage and apoptotic cell death in rapidly dividing cells. Carmustine is utilized in the treatment of various cancers, including brain tumors, Hodgkin’s disease, and multiple myeloma.
| Catalog Number | I001956 |
| CAS Number | 154-93-8 |
| Synonyms | (Z)-N,N/’-bis(2-chloroethyl)-N-nitrosocarbamimidic acid |
| Molecular Formula | C5H9Cl2N3O2 |
| Purity | ≥95% |
| Target | DNA Alkylator/Crosslinker |
| Solubility | DMSO: ≥ 35 mg/mL |
| Storage | Store at -20C |
| InChI | InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11) |
| InChIKey | DLGOEMSEDOSKAD-UHFFFAOYSA-N |
| SMILES | ClCCNC(N(N=O)CCCl)=O |
| Reference | </br>1:Verapamil augments carmustine- and irradiation-induced senescence in glioma cells by reducing intracellular reactive oxygen species and calcium ion levels. Ham SW, Jeon HY, Kim H.Tumour Biol. 2017 May;39(5):1010428317692244. doi: 10.1177/1010428317692244. PMID: 28459217 </br>2:Combination of carmustine and selenite Inhibits EGFR mediated growth signaling in androgen-independent prostate cancer cells. Thamilselvan V, Menon M, Stein GS, Valeriote F, Thamilselvan S.J Cell Biochem. 2017 Apr 21. doi: 10.1002/jcb.26086. [Epub ahead of print] PMID: 28430389 </br>3:Evaluation of O6-Benzylguanine-Potentiated Topical Carmustine for Mycosis Fungoides: A Phase 1-2 Clinical Trial. Tacastacas JD, Chan DV, Carlson S, Gerson SL, Dowlati A, Fu P, Lu K, Groft S, Rosenjack J, Honda K, McCormick TS, Cooper KD.JAMA Dermatol. 2017 May 1;153(5):413-420. doi: 10.1001/jamadermatol.2016.5793. PMID: 28199478 </br>4:Mathematical Modelling of Convection Enhanced Delivery of Carmustine and Paclitaxel for Brain Tumour Therapy. Zhan W, Arifin DY, Lee TK, Wang CH.Pharm Res. 2017 Apr;34(4):860-873. doi: 10.1007/s11095-017-2114-6. Epub 2017 Feb 2. PMID: 28155074 </br>5:Carmustine replacement in intensive chemotherapy preceding reinjection of autologous HSCs in Hodgkin and non-Hodgkin lymphoma: a review. Damaj G, Cornillon J, Bouabdallah K, Gressin R, Vigouroux S, Gastinne T, Ranchon F, Ghésquières H, Salles G, Yakoub-Agha I, Gyan E.Bone Marrow Transplant. 2017 Jan 23. doi: 10.1038/bmt.2016.340. [Epub ahead of print] Review. PMID: 28112752 </br>6:Polifeprosan 20, 3.85% carmustine slow release wafer in malignant glioma: patient selection and perspectives on a low-burden therapy. Kleinberg L.Patient Prefer Adherence. 2016 Nov 24;10:2397-2406. eCollection 2016. Review. PMID: 27920506 Free PMC Article</br>7:Topical Carmustine as Monotherapy or as Multimodality Therapy for Folliculotropic Mycosis Fungoides. MacArthur KM, Jariwala N, Kim EJ, Rook AH.Acta Derm Venereol. 2017 Mar 10;97(3):373-374. doi: 10.2340/00015555-2551. No abstract available. PMID: 27868149 Free Article</br>8:iRGD-mediated core-shell nanoparticles loading carmustine and O<sup>6</sup>-benzylguanine for glioma therapy. Liu C, Yao S, Li X, Wang F, Jiang Y.J Drug Target. 2017 Mar;25(3):235-246. doi: 10.1080/1061186X.2016.1238091. Epub 2016 Oct 6. PMID: 27646474 </br>9:Reduction of Atherosclerotic Lesions by the Chemotherapeutic Agent Carmustine Associated to Lipid Nanoparticles. Daminelli EN, Martinelli AE, Bulgarelli A, Freitas FR, Maranhão RC.Cardiovasc Drugs Ther. 2016 Oct;30(5):433-443. PMID: 27628679 </br>10:Infusion reactions are common after high-dose carmustine in BEAM chemotherapy and are not reduced by lengthening the time of administration. Perreault S, Baker J, Medoff E, Pratt K, Foss F, Isufi I, Seropian S, Cooper DL.Support Care Cancer. 2017 Jan;25(1):205-208. Epub 2016 Sep 10. PMID: 27614867 |
