Carnosol

• CAT Number: R007029
• CAS Number: 5957-80-2
• Molecular Formula: C20H26O4
• Molecular Weight: 330.42
• Purity: ≥95%
• Synonyms: 1,3,4,9,10,10aS-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-isopropyl-2H-9S,4aR-(epoxymethano)phenanthren-12-one
• Target: NF-κB
• Storage: -20°C
• IUPAC Name: (1R,8S,10S)-3,4-dihydroxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[6.6.2.01,10.02,7]hexadeca-2,4,6-trien-15-one
• InChI: InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1
• InChIKey: XUSYGBPHQBWGAD-PJSUUKDQSA-N
• SMILES: CC(C)C1=C(C(=C2C(=C1)C3CC4C2(CCCC4(C)C)C(=O)O3)O)O

Carnosol (Cat.No:R007029) is one of the phenolic antioxidants present in extracts of the herb rosemary (Rosmarinus officinalis). Carnosol inhibits the formation of tumors derived using irritants such as TPA and DMBA in murine models of carcinogenesis. The effective dose reported is 1-<wbr></wbr>10 µM topically or 6 µg/ml when added to supernatants of cultured cells. Addition of rosemary extracts to the diet as a 1% supplement by weight was also found to decrease the frequency of DMBA-<wbr></wbr>DNA adducts.