Carotegrast methyl

• CAT Number: I002145
• CAS Number: 401905-67-7
• PubChem Substance ID: 9872780
• Molecular Formula: C28H26Cl2N4O5
• Molecular Weight: 569.44
• Purity: ≥95%
• Target: Integrin
• IUPAC Name: methyl (2S)-2-[(2,6-dichlorobenzoyl)amino]-3-[4-[6-(dimethylamino)-1-methyl-2,4-dioxoquinazolin-3-yl]phenyl]propanoate
• InChI: InChI=1S/C28H26Cl2N4O5/c1-32(2)18-12-13-23-19(15-18)26(36)34(28(38)33(23)3)17-10-8-16(9-11-17)14-22(27(37)39-4)31-25(35)24-20(29)6-5-7-21(24)30/h5-13,15,22H,14H2,1-4H3,(H,31,35)/t22-/m0/s1
• InChIKey: MMHHPKCJJIFLBQ-QFIPXVFZSA-N
• SMILES: CN1C2=C(C=C(C=C2)N(C)C)C(=O)N(C1=O)C3=CC=C(C=C3)CC(C(=O)OC)NC(=O)C4=C(C=CC=C4Cl)Cl

Carotegrast Methyl(CAT: I002145) is a small molecule and orally active integrin antagonist, primarily targeting α4 integrin, widely utilized in gastrointestinal and immunology research. It inhibits leukocyte adhesion and migration by blocking α4 integrin interactions with vascular cell adhesion molecules (VCAM-1), making it valuable for studying inflammatory bowel disease (IBD) and other autoimmune disorders. Researchers explore Carotegrast Methyl for its potential therapeutic applications in conditions like ulcerative colitis and Crohn’s disease. With its high specificity and oral bioavailability, Carotegrast Methyl serves as a critical tool for preclinical and clinical studies aimed at developing novel treatments for immune-mediated inflammatory diseases.