Carprofen

• CAT Number: A000495
• CAS Number: 53716-49-7
• Molecular Formula: C15H12ClNO2
• Molecular Weight: 273.7
• Purity: ≥95%
• Synonyms: 53716-49-7; 2-(6-Chloro-9H-carbazol-2-yl)propanoic acid; Rimadyl; Imadyl; Ridamyl
• Target: Neuronal Signaling
• Storage: -20°C
• InChI: 1S/C15H12ClNO2/c1-8(15(18)19)9-2-4-11-12-7-10(16)3-5-13(12)17-14(11)6-9/h2-8,17H,1H3,(H,18,19)
• InChIKey: PUXBGTOOZJQSKH-UHFFFAOYSA-N
• SMILES: CC(C1=CC2=C(C=C1)C3=C(N2)C=CC(=C3)Cl)C(=O)O

Carprofen is a non-steroidal anti-inflammatory drug that veterinarians prescribe as a supportive treatment for various conditions. It provides day-to-day treatment for pain and inflammation from arthritis in geriatric dogs, joint pain, osteoarthritis, hip dysplasia, and other forms of joint deterioration. It is also used to relieve short-term post-operative pain, inflammation, and swelling after spaying, neutering, and other procedures. Carprofen reduces inflammation by inhibition of COX-2 and other sources of inflammatory prostaglandins. This is targeted protection, in that it does not interfere with COX-1 activity.

Reference

1: Capsoni D, Quinzeni I, Bruni G, Friuli V, Maggi L, Bini M. Improving the
Carprofen Solubility: Synthesis of the Zn(2)Al-LDH Hybrid Compound. J Pharm Sci.
2017 Oct 5. pii: S0022-3549(17)30676-7. doi: 10.1016/j.xphs.2017.09.019. [Epub
ahead of print] PubMed PMID: 28987499.

2: Naidoo V, Taggart MA, Duncan N, Wolter K, Chipangura J, Green RE, Galligan TH.
The use of toxicokinetics and exposure studies to show that carprofen in cattle
tissue could lead to secondary toxicity and death in wild vultures. Chemosphere.
2018 Jan;190:80-89. doi: 10.1016/j.chemosphere.2017.08.167. Epub 2017 Sep 14.
PubMed PMID: 28985539.

3: Nenadović K, Vučinić M, Radenković-Damnjanović B, Janković L, Teodorović R,
Voslarova E, Becskei Z. Cortisol concentration, pain and sedation scale in free
roaming dogs treated with carprofen after ovariohysterectomy. Vet World. 2017
Aug;10(8):888-894. doi: 10.14202/vetworld.2017.888-894. Epub 2017 Aug 9. PubMed
PMID: 28919678; PubMed Central PMCID: PMC5591474.

4: Li J, Ma LY, Li LS, Xu L. Photodegradation kinetics, transformation, and
toxicity prediction of ketoprofen, carprofen, and diclofenac acid in aqueous
solutions. Environ Toxicol Chem. 2017 Jul 18. doi: 10.1002/etc.3915. [Epub ahead
of print] PubMed PMID: 28718961.

5: Simonek GD, Alarcio GG, Brignolo LL. Sterility and Stability of Diluted
Carprofen in a Multidose Vial in the Laboratory Animal Setting. J Am Assoc Lab
Anim Sci. 2017 May 1;56(3):296-298. PubMed PMID: 28535864; PubMed Central PMCID:
PMC5438923.

6: Fukui S, Ooyama N, Tamura J, Umar MA, Ishizuka T, Itami T, Miyoshi K, Sano T,
Yamashita K. Interaction between maropitant and carprofen on sparing of the
minimum alveolar concentration for blunting adrenergic response (MAC-BAR) of
sevoflurane in dogs. J Vet Med Sci. 2017 Mar 18;79(3):502-508. doi:
10.1292/jvms.15-0666. Epub 2017 Jan 21. PubMed PMID: 28111373; PubMed Central
PMCID: PMC5383168.

7: Schulze I, Poos EM, Meyer H, List AK, Kaestner SB, Rehage J. Effects of
preoperative carprofen on cardio-respiratory, hormonal and metabolic stress
response in calves during umbilical surgery under isoflurane inhalation
anaesthesia. Vet J. 2016 Oct;216:18-24. doi: 10.1016/j.tvjl.2016.06.009. Epub
2016 Jun 28. PubMed PMID: 27687921.

8: Hedenqvist P, Trbakovic A, Thor A, Ley C, Ekman S, Jensen-Waern M. Carprofen
neither reduces postoperative facial expression scores in rabbits treated with
buprenorphine nor alters long term bone formation after maxillary sinus grafting.
Res Vet Sci. 2016 Aug;107:123-31. doi: 10.1016/j.rvsc.2016.05.010. Epub 2016 May
25. PubMed PMID: 27473985.

9: Brochmann RP, Helmfrid A, Jana B, Magnowska Z, Guardabassi L. Antimicrobial
synergy between carprofen and doxycycline against methicillin-resistant
Staphylococcus pseudintermedius ST71. BMC Vet Res. 2016 Jun 24;12(1):126. doi:
10.1186/s12917-016-0751-3. PubMed PMID: 27342694; PubMed Central PMCID:
PMC4921001.

10: Seymour TL, Adams SC, Felt SA, Jampachaisri K, Yeomans DC, Pacharinsak C.
Postoperative Analgesia Due to Sustained-Release Buprenorphine, Sustained-Release
Meloxicam, and Carprofen Gel in a Model of Incisional Pain in Rats (Rattus
norvegicus). J Am Assoc Lab Anim Sci. 2016;55(3):300-5. PubMed PMID: 27177563;
PubMed Central PMCID: PMC4865691.