For research use only. Not for therapeutic Use.
Casein Kinase Inhibitor A51（Cat No.:I044382）is a selective and cell-permeable inhibitor primarily targeting Casein Kinase 1 (CK1) isoforms, especially CK1δ and CK1ε. It modulates key cellular pathways such as Wnt signaling and circadian rhythm regulation, which are implicated in various cancers and neurodegenerative conditions. A51 demonstrates potent enzymatic inhibition with minimal off-target activity, making it a valuable tool for dissecting CK1-related signaling networks. Its pharmacological profile supports applications in both in vitro assays and in vivo models, aiding the exploration of CK1’s role in disease development and progression.
| CAS Number | 2079068-74-7 |
| Synonyms | 4-N-[5-chloro-4-[5-(cyclopropylmethyl)-1-methylpyrazol-4-yl]pyrimidin-2-yl]cyclohexane-1,4-diamine |
| Molecular Formula | C18H25ClN6 |
| Purity | ≥95% |
| IUPAC Name | 4-N-[5-chloro-4-[5-(cyclopropylmethyl)-1-methylpyrazol-4-yl]pyrimidin-2-yl]cyclohexane-1,4-diamine |
| InChI | InChI=1S/C18H25ClN6/c1-25-16(8-11-2-3-11)14(9-22-25)17-15(19)10-21-18(24-17)23-13-6-4-12(20)5-7-13/h9-13H,2-8,20H2,1H3,(H,21,23,24) |
| InChIKey | RVZJFCNYSSUDCU-UHFFFAOYSA-N |
| SMILES | CN1C(=C(C=N1)C2=NC(=NC=C2Cl)NC3CCC(CC3)N)CC4CC4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
