For research use only. Not for therapeutic Use.
CASIN(Cat No.:I003525)is a small molecule inhibitor specifically targeting Cdc42, a Rho family GTPase involved in cell signaling, cytoskeletal organization, and cell migration. By inhibiting Cdc42, CASIN disrupts pathways crucial for processes such as stem cell function, immune cell regulation, and cancer cell migration. CASIN has been widely used in research to study the role of Cdc42 in hematopoietic stem cell aging and rejuvenation, as well as in cancer metastasis. Its ability to modulate Cdc42 activity makes it a valuable tool for exploring therapeutic strategies in aging and cancer research.
Catalog Number | I003525 |
CAS Number | 425399-05-9 |
Synonyms | 2-((6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethanol |
Molecular Formula | C20H22N2O |
Purity | ≥95% |
Target | Cdc42 |
Solubility | Soluble to 100 mM in DMSO and to 50 mM in ethanol |
Storage | Store at -20°C |
IUPAC Name | 2-[(6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino]ethanol |
InChI | InChI=1S/C20H22N2O/c23-12-11-21-19-8-4-7-16-17-13-15(14-5-2-1-3-6-14)9-10-18(17)22-20(16)19/h1-3,5-6,9-10,13,19,21-23H,4,7-8,11-12H2 |
InChIKey | RXIUMAOXORBRCY-UHFFFAOYSA-N |
SMILES | C1CC(C2=C(C1)C3=C(N2)C=CC(=C3)C4=CC=CC=C4)NCCO |
Reference | </br>1:A promising yellow phosphor of Ce3+/Li+ doped CaSiN(2-2δ/3)Oδ for pc-LEDs. Wang XM, Zhang X, Ye S, Jing XP.Dalton Trans. 2013 Apr 14;42(14):5167-73. doi: 10.1039/c3dt32582b. PMID: 23403647 </br>2:Diversity and evolution of the microbial populations during manufacture and ripening of Casín, a traditional Spanish, starter-free cheese made from cow/’s milk. Alegría A, Alvarez-Martín P, Sacristán N, Fernández E, Delgado S, Mayo B.Int J Food Microbiol. 2009 Nov 30;136(1):44-51. doi: 10.1016/j.ijfoodmicro.2009.09.023. Epub 2009 Sep 30. PMID: 19822375 </br>3:Synthesis and structure of alkaline earth silicon nitrides: BaSiN(2), SrSiN(2), and CaSiN(2). Gál ZA, Mallinson PM, Orchard HJ, Clarke SJ.Inorg Chem. 2004 Jun 28;43(13):3998-4006. PMID: 15206881 </br>4:[EXPERIMENT WITH A PLASMIN PREPARATION BY USING THE CASIN SPLITTING TEST: THE ACTION OF PLASMIN-NOVO AND ITS INHIBITION WITH EPSILON-AMINOCAPROIC ACID AND TRASYLOL]. BERGHOFF A, GLATZEL H.Thromb Diath Haemorrh. 1964 Dec 31;12:418-24. German. No abstract available. PMID: 14254701 </br>5:Studies on the influence of minute amounts of fatty acids in bacteriological culture media on bacterial growth (I). Growth-accelerating action of trace amounts of fatty acids in vitamin-free casin acid-hydrolysate on Streptococcus hemolyticus strain S-8. ARAI T, KUWAHARA S.Jpn J Microbiol. 1961 Jul;5:327-35. No abstract available. PMID: 14013520 Free Article |