For research use only. Not for therapeutic Use.
Caspase-9 Inhibitor III（Cat No.:I042326）is a synthetic compound designed to inhibit caspase-9, an enzyme that plays a key role in the apoptotic (programmed cell death) pathway, specifically in the intrinsic (mitochondrial) apoptotic pathway. Caspase-9 activation triggers a cascade of events leading to cell death, which is important for regulating cell turnover and eliminating damaged cells. By inhibiting caspase-9, Caspase-9 Inhibitor III can potentially protect cells from unwanted apoptosis, making it useful in research related to neurodegenerative diseases, cancer, and other conditions where controlling cell death is crucial.
| CAS Number | 403848-57-7 |
| Synonyms | (4S)-4-[[(2S)-2-acetamido-4-methylpentanoyl]amino]-5-[[(2S)-1-[[(2S)-1-carboxy-4-chloro-3-oxobutan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid |
| Molecular Formula | C24H35ClN6O9 |
| Purity | ≥95% |
| IUPAC Name | 4-[(2-acetamido-4-methylpentanoyl)amino]-5-[[1-[(1-carboxy-4-chloro-3-oxobutan-2-yl)amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid |
| InChI | InChI=1S/C24H35ClN6O9/c1-12(2)6-17(28-13(3)32)23(39)29-15(4-5-20(34)35)22(38)31-18(7-14-10-26-11-27-14)24(40)30-16(8-21(36)37)19(33)9-25/h10-12,15-18H,4-9H2,1-3H3,(H,26,27)(H,28,32)(H,29,39)(H,30,40)(H,31,38)(H,34,35)(H,36,37) |
| InChIKey | JSRLQUNMFYXVQD-UHFFFAOYSA-N |
| SMILES | CC(C)CC(C(=O)NC(CCC(=O)O)C(=O)NC(CC1=CN=CN1)C(=O)NC(CC(=O)O)C(=O)CCl)NC(=O)C |
| Reference | [1]. Sodhi RK, et, al. Protective effects of caspase-9 and poly(ADP-ribose) polymerase inhibitors on ischemia-reperfusion-induced myocardial injury. Arch Pharm Res. 2009 Jul;32(7):1037-43. [2]. Castro MM, et, al. Inhibitory effects of caspase inhibitors on the activity of matrix metalloproteinase-2. Biochem Pharmacol. 2013 Aug 15;86(4):469-75. |
