Caspofungin Acetate

For research use only. Not for therapeutic Use.

  • CAT Number: I013966
  • CAS Number: 179463-17-3
  • Molecular Formula: C₅₆H₉₆N₁₀O₁₉
  • Molecular Weight: 1213.42
  • Purity: 99%
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Caspofungin Acetate(Cat No.:I013966)is an antifungal agent used primarily in the treatment of invasive fungal infections, including candidiasis and aspergillosis. It works by inhibiting the synthesis of glucan, a key component of fungal cell walls, thereby impairing cell integrity and leading to cell death. As a member of the echinocandin class of drugs, Caspofungin Acetate is administered intravenously and is effective against resistant fungal strains. It is commonly used in immunocompromised patients, including those with hematologic malignancies or organ transplants, where fungal infections pose significant risks.


Catalog Number I013966
CAS Number 179463-17-3
Molecular Formula C₅₆H₉₆N₁₀O₁₉
Purity 99%
Target Fungal
Solubility H2O: ≥ 100 mg/mL
Appearance White Powder
Analysis method HPLC
IUPAC Name acetic acid;N-[(3S,6S,9S,11R,15S,18S,20R,21S,24S,25S)-21-(2-aminoethylamino)-3-[(1R)-3-amino-1-hydroxypropyl]-6-[(1S,2S)-1,2-dihydroxy-2-(4-hydroxyphenyl)ethyl]-11,20,25-trihydroxy-15-[(1R)-1-hydroxyethyl]-2,5,8,14,17,23-hexaoxo-1,4,7,13,16,22-hexazatricyclo[22.3.0.09,13]heptacosan-18-yl]-10,12-dimethyltetradecanamide
InChI InChI=1S/C52H88N10O15.2C2H4O2/c1-5-28(2)24-29(3)12-10-8-6-7-9-11-13-39(69)56-34-26-38(68)46(55-22-21-54)60-50(75)43-37(67)19-23-61(43)52(77)41(36(66)18-20-53)58-49(74)42(45(71)44(70)31-14-16-32(64)17-15-31)59-48(73)35-25-33(65)27-62(35)51(76)40(30(4)63)57-47(34)72;2*1-2(3)4/h14-17,28-30,33-38,40-46,55,63-68,70-71H,5-13,18-27,53-54H2,1-4H3,(H,56,69)(H,57,72)(H,58,74)(H,59,73)(H,60,75);2*1H3,(H,3,4)/t28?,29?,30-,33-,34+,35+,36-,37+,38-,40+,41+,42+,43+,44+,45+,46+;;/m1../s1
InChIKey OGUJBRYAAJYXQP-LLXMLGLCSA-N
SMILES CCC(C)CC(C)CCCCCCCCC(=O)N[C@H]1C[C@H]([C@H](NC(=O)[C@@H]2[C@H](CCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]3C[C@H](CN3C(=O)[C@@H](NC1=O)[C@@H](C)O)O)[C@@H]([C@H](C4=CC=C(C=C4)O)O)O)[C@@H](CCN)O)O)NCCN)O.CC(=O)O.CC(=O)O
Reference

[1]. Mojumder DK, et al. Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye. Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5796-803.<br />
[2]. Flattery, Amy M. et al. Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis. Antimicrobial Agents and Chemotherapy (2011), 55(7), 3491-3497.

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