For research use only. Not for therapeutic Use.
Catalpol（Cat No.:I002805）is a naturally occurring iridoid glycoside found in plants such as Rehmannia glutinosa and Scrophularia species. It exhibits a wide range of pharmacological activities, including antioxidant, anti-inflammatory, neuroprotective, and antidiabetic effects. Catalpol is particularly studied for its potential in treating neurodegenerative disorders like Alzheimer’s and Parkinson’s by modulating oxidative stress and inflammation. It also shows promise in protecting against cardiovascular damage and improving glucose metabolism. As a bioactive compound with diverse therapeutic applications, Catalpol continues to be a focus in drug discovery and natural product research.
| Catalog Number | I002805 |
| CAS Number | 2415-24-9 |
| Molecular Formula | C15H22O10 |
| Purity | ≥95% |
| Target | neuroprotective, anti-inflammatory, and anti-hepatitis virus natural product. |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | (2S,3R,4S,5S,6R)-2-[[(1S,2S,4S,5S,6R,10S)-5-hydroxy-2-(hydroxymethyl)-3,9-dioxatricyclo[4.4.0.02,4]dec-7-en-10-yl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol |
| InChI | InChI=1S/C15H22O10/c16-3-6-9(19)10(20)11(21)14(23-6)24-13-7-5(1-2-22-13)8(18)12-15(7,4-17)25-12/h1-2,5-14,16-21H,3-4H2/t5-,6-,7-,8+,9-,10+,11-,12+,13+,14+,15-/m1/s1 |
| InChIKey | LHDWRKICQLTVDL-PZYDOOQISA-N |
| SMILES | C1=CO[C@H]([C@H]2[C@@H]1[C@@H]([C@H]3[C@@]2(O3)CO)O)O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O |
| Reference | </br>1:Effect of catalpol on remyelination through experimental autoimmune encephalomyelitis acting to promote Olig1 and Olig2 expressions in mice. Yang T, Zheng Q, Wang S, Fang L, Liu L, Zhao H, Wang L, Fan Y.BMC Complement Altern Med. 2017 May 2;17(1):240. doi: 10.1186/s12906-017-1642-2. PMID: 28464811 Free PMC Article</br>2:Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells. Liu Y, Tang Q, Shao S, Chen Y, Chen W, Xu X.Int J Biol Sci. 2017 Feb 25;13(3):327-338. doi: 10.7150/ijbs.17751. eCollection 2017. PMID: 28367097 Free PMC Article</br>3:Catalpol protects glucose-deprived rat embryonic cardiac cells by inducing mitophagy and modulating estrogen receptor. Lin C, Lu Y, Yan X, Wu X, Kuai M, Sun X, Chen Q, Kong X, Liu Z, Tang Y, Jing Y, Li Y, Zhang Q, Bian H.Biomed Pharmacother. 2017 May;89:973-982. doi: 10.1016/j.biopha.2017.02.069. Epub 2017 Mar 9. PMID: 28292026 </br>4:Catalpol Protects Pre-Myelinating Oligodendrocytes against Ischemia-induced Oxidative Injury through ERK1/2 Signaling Pathway. Cai Q, Ma T, Li C, Tian Y, Li H.Int J Biol Sci. 2016 Oct 26;12(12):1415-1426. eCollection 2016. PMID: 27994507 Free PMC Article</br>5:Catalpol alleviates ovalbumin-induced asthma in mice: Reduced eosinophil infiltration in the lung. Chen Y, Zhang Y, Xu M, Luan J, Piao S, Chi S, Wang H.Int Immunopharmacol. 2017 Feb;43:140-146. doi: 10.1016/j.intimp.2016.12.011. Epub 2016 Dec 16. PMID: 27992791 </br>6:Catalpol ameliorates diabetic atherosclerosis in diabetic rabbits. Liu JY, Zheng CZ, Hao XP, Zhang DJ, Mao AW, Yuan P.Am J Transl Res. 2016 Oct 15;8(10):4278-4288. eCollection 2016. PMID: 27830011 Free PMC Article</br>7:Catalpol restores LPS-elicited rat microcirculation disorder by regulation of a network of signaling involving inhibition of TLR-4 and SRC. Zhang YP, Pan CS, Yan L, Liu YY, Hu BH, Chang X, Li Q, Huang DD, Sun HY, Fu G, Sun K, Fan JY, Han JY.Am J Physiol Gastrointest Liver Physiol. 2016 Dec 1;311(6):G1091-G1104. doi: 10.1152/ajpgi.00159.2016. Epub 2016 Oct 27. PMID: 27789455 </br>8:Simultaneous Determination of Catalpol, Aucubin, and Geniposidic Acid in Different Developmental Stages of Rehmannia glutinosa Leaves by High Performance Liquid Chromatography. Wang Y, Liao D, Qin M, Li X.J Anal Methods Chem. 2016;2016:4956589. doi: 10.1155/2016/4956589. Epub 2016 Jun 26. PMID: 27429834 Free PMC Article</br>9:Catalpol stimulates VEGF production via the JAK2/STAT3 pathway to improve angiogenesis in rats/’ stroke model. Dong W, Xian Y, Yuan W, Huifeng Z, Tao W, Zhiqiang L, Shan F, Ya F, Hongli W, Jinghuan W, Lei Q, Li Z, Hongyi Q.J Ethnopharmacol. 2016 Sep 15;191:169-79. doi: 10.1016/j.jep.2016.06.030. Epub 2016 Jun 11. PMID: 27301615 </br>10:Antidiabetic and antioxidant effects of catalpol extracted from Rehmannia glutinosa (Di Huang) on rat diabetes induced by streptozotocin and high-fat, high-sugar feed. Zhu H, Wang Y, Liu Z, Wang J, Wan D, Feng S, Yang X, Wang T.Chin Med. 2016 May 11;11:25. doi: 10.1186/s13020-016-0096-7. eCollection 2016. PMID: 27175212 Free PMC Article |
