For research use only. Not for therapeutic Use.
Catharanthine inhibits nicotinic receptor mediated diaphragm contractions with IC50 of 59.6 μM.<br>Catharanthine evokes a concentration-dependent attenuation of carbachol responses in the rat ileum preparation, producing rightward curve displacements and decreases in maximal agonist responses. The mixture of serpentine, plus ajmalicine and catharanthine reveals a concentration-dependent inhibitory effect of acethylcholinesterase (AchE), with an IC50 at ca. 2.25 μg/mL.
| Catalog Number | A000201 |
| CAS Number | 2468-21-5 |
| Synonyms | NA |
| Molecular Formula | C₂₁H₂₄N₂O₂ |
| Purity | ≥95% |
| Target | Neuronal Signaling |
| Storage | 3 years -20C powder |
| InChI | InChI=1S/C21H24N2O2/c1-3-14-10-13-11-21(20(24)25-2)18-16(8-9-23(12-13)19(14)21)15-6-4-5-7-17(15)22-18/h4-7,10,13,19,22H,3,8-9,11-12H2,1-2H3 |
| InChIKey | CMKFQVZJOWHHDV-UHFFFAOYSA-N |
| SMILES | CCC1=CC2CC3(C1N(C2)CCC4=C3NC5=CC=CC=C45)C(=O)OC |
