Cathepsin K inhibitor 6

• CAT Number: I043651
• CAS Number: 325775-42-6
• Molecular Formula: C11H13N3O2S
• Molecular Weight: 251.30
• Purity: ≥95%
• Synonyms: N-[(1-cyanoazetidin-3-yl)methyl]benzenesulfonamide
• InChI: InChI=1S/C11H13N3O2S/c12-9-14-7-10(8-14)6-13-17(15,16)11-4-2-1-3-5-11/h1-5,10,13H,6-8H2
• InChIKey: UIOWYXXRERXCMP-UHFFFAOYSA-N
• SMILES: C1C(CN1C#N)CNS(=O)(=O)C2=CC=CC=C2

Cathepsin K inhibitor 6 (compound 19) is an inhibitor of cathepsin K (Cat K) with an IC50 of 17 nM. Cathepsin K inhibitor 6 also has inhibitory effects on other isoforms, with IC50s of 0.05 μM (Cat L) and 0.3 μM (Cat B), respectively[1].

Reference

[1]. Falgueyret JP, et al. Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L. J Med Chem. 2001 Jan 4;44(1):94-104.
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