Cathepsin X-IN-1

• CAT Number: I043674
• CAS Number: 2418577-51-0
• Molecular Formula: C15H13N3O3S
• Molecular Weight: 315.35
• Purity: ≥95%
• Synonyms: 2-[2-[2-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-oxoethyl]sulfanylimidazol-1-yl]acetonitrile
• InChI: InChI=1S/C15H13N3O3S/c16-3-5-18-6-4-17-15(18)22-10-12(19)11-1-2-13-14(9-11)21-8-7-20-13/h1-2,4,6,9H,5,7-8,10H2
• InChIKey: PTNGAXZNCFUKJN-UHFFFAOYSA-N
• SMILES: C1COC2=C(O1)C=CC(=C2)C(=O)CSC3=NC=CN3CC#N

Cathepsin X-IN-1 (compound 25) is a potent Cathepsin X inhibitor with an IC50 of 7.13 µM. Cathepsin X-IN-1 decreases PC-3 cell migration with low cytotoxic[1].

Reference

[1]. Fonović UP, et al. Structure-activity relationships of triazole-benzodioxine inhibitors of cathepsin X. Eur J Med Chem. 2020 May 1;193:112218.
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