For research use only. Not for therapeutic Use.
CATPB is a potent, selective free fatty acid receptor 2 (FFA2R/GPR43) antagonist[1].
CATPB inhibits the transient rise in intracellular Ca2+ induced in neutrophils by acetate or Cmp1 (FFAR2 agonist)[1].
CATPB inhibits Cmp1-induced NADPH oxidase activity[1].
| Catalog Number | I011328 |
| CAS Number | 1322598-09-3 |
| Synonyms | (3S)-3-[[2-(3-chlorophenyl)acetyl]amino]-4-[4-(trifluoromethyl)phenyl]butanoic acid |
| Molecular Formula | C19H17ClF3NO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C19H17ClF3NO3/c20-15-3-1-2-13(8-15)10-17(25)24-16(11-18(26)27)9-12-4-6-14(7-5-12)19(21,22)23/h1-8,16H,9-11H2,(H,24,25)(H,26,27)/t16-/m0/s1 |
| InChIKey | QOSIJVVNNGXEKE-INIZCTEOSA-N |
| SMILES | C1=CC(=CC(=C1)Cl)CC(=O)NC(CC2=CC=C(C=C2)C(F)(F)F)CC(=O)O |
| Reference | [1]. Lena Björkman, et al. The Neutrophil Response Induced by an Agonist for Free Fatty Acid Receptor 2 (GPR43) Is Primed by Tumor Necrosis Factor Alpha and by Receptor Uncoupling from the Cytoskeleton but Attenuated by Tissue Recruitment. Mol Cell Biol. 2016 Sep 26;36(20):2583-95. |
