For research use only. Not for therapeutic Use.
Catumaxomab, a trifunctional IgG2 antibody, is composed of mouse and rat heavy and light chains and binds to human EpCAM and human CD 3 receptors. The Fc region of Catumaxomab region has binding affinity for FcγR1 (CD 64), FcγRIIA (CD 32a), and FcγRIII (CD 16). Catumaxomab can be used for anti-tumor research, especially epithelial cancers[1][2].
Catumaxomab (0-5 ng/mL; 3-7 days) strongly inhibits the growth of FaDu tumor spheroids in coculture with PBMC with a dose-dependent manner[2].
| Catalog Number | I040653 |
| CAS Number | 509077-98-9 |
| Purity | ≥95% |
| Reference | [1]. Mansoor M. Amiji, et.al. Chapter Two – Innate and adaptive immunity in cancer. Cancer Immunology and Immunotherapy. Academic Press, 2022, Pages 19-61. [2]. Hirschhaeuser F, et.al. Efficacy of catumaxomab in tumor spheroid killing is mediated by its trifunctional mode of action. Cancer Immunol Immunother. 2010 Nov;59(11):1675-84. |
