Catumaxomab

• CAT Number: I040653
• CAS Number: 509077-98-9
• Purity: ≥95%

Catumaxomab(CAT: I040653) is a trifunctional monoclonal antibody engineered to target epithelial cell adhesion molecule (EpCAM) on tumor cells and CD3 on T-cells, while simultaneously engaging Fcγ receptors on accessory immune cells. This unique structure facilitates potent immune cell-mediated cytotoxicity, making Catumaxomab effective in directing immune responses against EpCAM-positive cancers, including ovarian, gastric, and colorectal carcinomas. It has been used clinically for the treatment of malignant ascites, demonstrating both tumor-reducing and immune-activating effects. Though withdrawn from the European market, it remains a valuable agent in oncology research.