Caulerpin

• CAT Number: I024162
• CAS Number: 26612-48-6
• Molecular Formula: C24H18N2O4
• Molecular Weight: 398.42
• Purity: 98%
• Synonyms: Caulerpin
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: Cycloocta(1,2-b:5,6-b')diindole-6,13-dicarboxylic acid, 5,12-dihydro-, dimethyl ester
• InChI: InChI=1S/C24H18N2O4/c1-29-23(27)17-11-15-13-7-3-6-10-20(13)26-22(15)18(24(28)30-2)12-16-14-8-4-5-9-19(14)25-21(16)17/h3-12,25-26H,1-2H3/b15-11-,16-12-,17-11+,18-12+,21-17-,22-18-
• InChIKey: PVWALMHWUOWPPA-HCOJNGAVSA-N
• SMILES: O=C(C1=C2NC3=C(C=CC=C3)C/2=C/C(C(OC)=O)=C4NC5=C(C=CC=C5)C/4=C/1)OC

Caulerpin (Cat No.: I024162) is a bioactive alkaloid isolated from Caulerpa algae, known for its diverse pharmacological properties, including anti-inflammatory, antioxidant, anticancer, and antimicrobial activities. Structurally, it features a bis-indole framework, contributing to its biological activity. Caulerpin has been studied for its potential in metabolic regulation, particularly in lipid metabolism and obesity-related disorders. Its unique chemical structure makes it a valuable compound in natural product research, offering potential therapeutic applications in drug discovery for various diseases, including cancer and metabolic syndromes.

Reference

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8: Ahmed SA, Abdelrheem DA, El-Mageed HRA, Mohamed HS, Rahman AA, Elsayed KNM, Ahmed SA. Destabilizing the structural integrity of COVID-19 by caulerpin and its derivatives along with some antiviral drugs: An in silico approaches for a combination therapy. Struct Chem. 2020 Jul 23:1-22. doi: 10.1007/s11224-020-01586-w. Epub ahead of print. PMID: 32837118; PMCID: PMC7376526.
9: Liu Y, Morgan JB, Coothankandaswamy V, Liu R, Jekabsons MB, Mahdi F, Nagle DG, Zhou YD. The Caulerpa pigment caulerpin inhibits HIF-1 activation and mitochondrial respiration. J Nat Prod. 2009 Dec;72(12):2104-9. doi: 10.1021/np9005794. PMID: 19921787; PMCID: PMC2798910.
10: Canché Chay CI, Gómez Cansino R, Espitia Pinzón CI, Torres-Ochoa RO, Martínez R. Synthesis and anti-tuberculosis activity of the marine natural product caulerpin and its analogues. Mar Drugs. 2014 Mar 27;12(4):1757-72. doi: 10.3390/md12041757. PMID: 24681629; PMCID: PMC4012461.