For research use only. Not for therapeutic Use.
CAY10444 (BML-241) is a sphingosine-1-phosphate 3 (S1P3) antagonist. CAY10444 inhibits by 37% S1P-induced increases in Ca2+ in HeLa cells expressing S1P3 receptors[1].
BML-241 inhibits increases in intracellular Ca2+ concentration via P2 receptor or α1A-adrenoceptor stimulation and α1A-adrenoceptor-mediated contraction of rat mesenteric artery, while it does not affect S1P3-mediated decrease of Forskolin-induced cyclic AMP accumulation[1].
| Catalog Number | R009238 |
| CAS Number | 298186-80-8 |
| Synonyms | (4R)-2-undecyl-1,3-thiazolidine-4-carboxylic acid |
| Molecular Formula | C15H29NO2S |
| Purity | ≥95% |
| InChI | InChI=1S/C15H29NO2S/c1-2-3-4-5-6-7-8-9-10-11-14-16-13(12-19-14)15(17)18/h13-14,16H,2-12H2,1H3,(H,17,18)/t13-,14?/m0/s1 |
| InChIKey | FNBSOIBCKUUVJJ-LSLKUGRBSA-N |
| SMILES | CCCCCCCCCCCC1NC(CS1)C(=O)O |
| Reference | [1]. Salvatore Salomone, et al. Selectivity and specificity of sphingosine-1-phosphate receptor ligands: caveats and critical thinking in characterizing receptor-mediated effects. Front Pharmacol. 2011 Feb 22;2:9. |
