CAY10603

• CAT Number: I000254
• CAS Number: 1045792-66-2
• Molecular Formula: C22H30N4O6
• Molecular Weight: 446.5
• Purity: ≥95%
• Synonyms: N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]carbonyl]-5-isoxazolyl]phenyl]-1,1-dimethylethyl ester, carbamic acid
• Target: Epigenetics
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IC50: 2 pM [1]
• IUPAC Name: tert-butyl N-[4-[3-[[7-(hydroxyamino)-7-oxoheptyl]carbamoyl]-1,2-oxazol-5-yl]phenyl]carbamate
• InChI: InChI=1S/C22H30N4O6/c1-22(2,3)31-21(29)24-16-11-9-15(10-12-16)18-14-17(26-32-18)20(28)23-13-7-5-4-6-8-19(27)25-30/h9-12,14,30H,4-8,13H2,1-3H3,(H,23,28)(H,24,29)(H,25,27)
• InChIKey: WWGBHDIHIVGYLZ-UHFFFAOYSA-N
• SMILES: CC(C)(C)OC(=O)NC1=CC=C(C=C1)C2=CC(=NO2)C(=O)NCCCCCCC(=O)NO

CAY10603 (Cat.No:I000254) is a potent and selective inhibitor of the mitotic kinase monopolar spindle 1 (MPS1). It has shown to selectively kill cancer cells by inducing a mitotic checkpoint and causing chromosome segregation errors. CAY10603 has been studied for its potential as an anti-cancer therapeutic agent in preclinical studies, with promising results. It is available for research purposes and is not approved for clinical use.

Reference

[1]. Kozikowski AP, et al. Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6. J Med Chem. 2008 Aug 14;51(15):4370-3.