For research use only. Not for therapeutic Use.
Prostaglandin E<sub>2</sub> (PGE<sub>2</sub>; Item No. <span class=/itemid/>14010</span>) activates four E prostanoid (EP) receptors, EP<sub>1-4</sub>. EP<sub>4</sub> is a G protein-coupled receptor that, by elevating the second messenger cAMP, plays important roles in bone formation and resorption, cancer, and atherosclerosis. CAY10684 is a lactam that acts as a potent EP<sub>4</sub> agonist, triggering cAMP signaling with an EC<sub>50</sub> value of 0.8 nM. It displays more than 1,000-fold selectivity for EP<sub>4</sub> over other EP receptors.
| Catalog Number | R065146 |
| CAS Number | 493035-81-7 |
| Synonyms | (2R)-2-[(1E)-3-(4/’-chloro-2/’-methyl[1,1/’-biphenyl]-3-yl)-3-hydroxy-1-propen-1-yl]-5-oxo-1-pyrrolidineheptanoic acid |
| Molecular Formula | C27H32ClNO4 |
| Purity | ≥95% |
| Target | Prostaglandin Receptor |
| Storage | -20°C |
| InChI | InChI=1S/C27H32ClNO4/c1-19-17-22(28)10-13-24(19)20-7-6-8-21(18-20)25(30)14-11-23-12-15-26(31)29(23)16-5-3-2-4-9-27(32)33/h6-8,10-11,13-14,17-18,23,25,30H,2-5,9,12,15-16H2,1H3,(H,32,33)/b14-11+/t23-,25?/m0/s1 |
| InChIKey | LMJHPADNCZPRCN-KSPGTVSPSA-N |
| SMILES | O=C1N(CCCCCCC(O)=O)[C@@H](/C=C/C(O)C2=CC(C(C=C3)=C(C)C=C3Cl)=CC=C2)CC1 |
| Reference | 1.Li, M.,Thompson, D.D., and Paralkar, V.M. Prostaglandin E2 receptors in bone formation. International Orthopaedics 31, 767-772 (2007). |
