CB-1158

• CAT Number: I005706
• CAS Number: 1345810-21-0
• Molecular Formula: C18H27BCl2N2O4
• Molecular Weight: 417.13
• Purity: ≥95%
• Synonyms: CB-1158; CB 1158; CB1158.;2-amino-6-borono-2-(1-(2,4-dichlorobenzyl)piperidin-4-yl)hexanoic acid
• Target: arginase inhibitor
• Solubility: Soluble in DMSO
• Storage: 0 - 4°C for short term ,or -20 °C for long term
• IUPAC Name: 2-amino-6-borono-2-[1-[(2,4-dichlorophenyl)methyl]piperidin-4-yl]hexanoic acid
• InChI: InChI=1S/C18H27BCl2N2O4/c20-15-4-3-13(16(21)11-15)12-23-9-5-14(6-10-23)18(22,17(24)25)7-1-2-8-19(26)27/h3-4,11,14,26-27H,1-2,5-10,12,22H2,(H,24,25)
• InChIKey: ISYBHIALKUAHGV-UHFFFAOYSA-N
• SMILES: B(CCCCC(C1CCN(CC1)CC2=C(C=C(C=C2)Cl)Cl)(C(=O)O)N)(O)O

CB-1158(CAT: I005706) (also known as INCB001158) is a potent and selective inhibitor of arginase 1 (ARG1), an enzyme that depletes L-arginine, a critical amino acid for T-cell function. By blocking ARG1, CB-1158 restores L-arginine levels, enhancing T-cell proliferation and anti-tumor immune responses. This mechanism makes CB-1158 a promising candidate in cancer immunotherapy, particularly for overcoming immune suppression within the tumor microenvironment. CB-1158 is being explored in combination with immune checkpoint inhibitors to improve therapeutic outcomes in various cancers by reactivating the immune system to target and eliminate tumor cells.