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289715-28-2-CB 300919 CB 300919

CB 300919

For research use only. Not for therapeutic Use.

  • CAT Number: I003000
  • CAS Number: 289715-28-2
  • Molecular Formula: C32H34ClN7O2
  • Molecular Weight: 584.11
  • Purity: ≥95%
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Related Small Molecules: Dalcetrapib     AL 8697     Octinoxate    

<p style=/line-height:25px/>CB 300919 is a water-soluble analogue of CB30865; has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft.<br>IC50 value:<br>Target: Nampt</p>


Catalog Number I003000
CAS Number 289715-28-2
Synonyms

4-[[7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide

Molecular Formula C32H34ClN7O2
Purity ≥95%
Target NAMPT
Solubility 10 mM in DMSO
Storage Store at -20°C
Reference

<p style=/line-height:25px/>
<br>[1]. Lockman, Jeffrey W. et al. Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as Potent Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt). J. Med. Chem., 2010, 53 (24), pp 8734-8746
<br>[2]. Bavetsias, V. et al. The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent. Journal of Medicinal Chemistry (2002), 45(17), 3692-3702.
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