For research use only. Not for therapeutic Use.
CB 300919(CAT: I003000) is a water-soluble analogue of CB30865, designed for enhanced bioavailability and therapeutic application. It exhibits a remarkable growth inhibition IC50 value of 2 nM in continuous 96-hour exposure studies using human CH1 ovarian tumor xenograft models. This high potency against cancer cells underscores its potential as a valuable tool in oncology research. CB 300919 is instrumental for studying tumor biology, evaluating anticancer efficacy, and developing targeted therapies for ovarian and other malignancies.
| Catalog Number | I003000 |
| CAS Number | 289715-28-2 |
| Synonyms | 4-[[7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide |
| Molecular Formula | C32H34ClN7O2 |
| Purity | ≥95% |
| Target | NAMPT |
| Solubility | 10 mM in DMSO |
| Storage | Store at -20°C |
| IUPAC Name | 4-[[7-chloro-3-methyl-2-[(4-methylpiperazin-1-yl)methyl]-4-oxoquinazolin-6-yl]methyl-prop-2-ynylamino]-N-(pyridin-3-ylmethyl)benzamide |
| InChI | InChI=1S/C32H34ClN7O2/c1-4-12-40(26-9-7-24(8-10-26)31(41)35-20-23-6-5-11-34-19-23)21-25-17-27-29(18-28(25)33)36-30(38(3)32(27)42)22-39-15-13-37(2)14-16-39/h1,5-11,17-19H,12-16,20-22H2,2-3H3,(H,35,41) |
| InChIKey | LWTCFUSGPRGUBX-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)CC2=NC3=C(C=C(C(=C3)Cl)CN(CC#C)C4=CC=C(C=C4)C(=O)NCC5=CN=CC=C5)C(=O)N2C |
