For research use only. Not for therapeutic Use.
CB096 selectively inhibited repeat associated non-ATG (RAN) translation and decreased the production of poly(GP) DPRs without affecting r(G4C2)66 mRNA levels in an HEK293T cellular model of c9ALS/FTD, alleviated dysfunctional nucleocytoplasmic transport, and selectively reduced the abundance of r(G4C2)66-induced stress granules. Moreover, CB096 is a selective binder to the r(G4C2)8 hairpin over r(G2C4)8 (antisense), r(GGCC)10 (base pair) RNAs, and other 1×1 internal loops.
KEYWORDS: CB096 | Supplier | RAN inhibitor | CB 096 | CB-096 | CAS [108883-90-5] | DNA-RNA | RAN | Inhibitor | Hypertension | Amyotrophic lateral sclerosis | ALS | Frontotemporal dementia | FTD
| Catalog Number | I024188 |
| CAS Number | 108883-90-5 |
| Molecular Formula | C14H11N3O4 |
| Purity | ≥95% |
| IUPAC Name | 2-methoxy-4-(6-nitro-1H-benzimidazol-2-yl)phenol |
| InChI | InChI=1S/C14H11N3O4/c1-21-13-6-8(2-5-12(13)18)14-15-10-4-3-9(17(19)20)7-11(10)16-14/h2-7,18H,1H3,(H,15,16) |
| SMILES | COC1=C(C=CC(=C1)C2=NC3=C(N2)C=C(C=C3)[N+](=O)[O-])O |
| Reference | G Navarrete-Vázquez et al. Synthesis, vasorelaxant activity and antihypertensive effect of benzo[d]imidazole derivatives. Bioorg Med Chem. 2010 Jun 1;18(11):3985-91. A Ursu et al. Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD. ACS Chem Biol. 2020 Dec 18;15(12):3112-3123. |
