CB1/2 agonist 3

• CAT Number: I043352
• CAS Number: 2772655-86-2
• Molecular Formula: C25H41NO2
• Molecular Weight: 387.60
• Purity: ≥95%
• Synonyms: N-cyclopropyl-11-(3-pentylphenoxy)undecanamide
• InChI: InChI=1S/C25H41NO2/c1-2-3-10-14-22-15-13-16-24(21-22)28-20-12-9-7-5-4-6-8-11-17-25(27)26-23-18-19-23/h13,15-16,21,23H,2-12,14,17-20H2,1H3,(H,26,27)
• InChIKey: ZWANZUMSTXYAJD-UHFFFAOYSA-N
• SMILES: CCCCCC1=CC(=CC=C1)OCCCCCCCCCCC(=O)NC2CC2

CB1/2 agonist 3 (compound 52), a potent non-selective cannabinoid ligand, is a CB1/CB2 (cannabinoid receptor) competitive agonist. CB1/2 agonist 3 acts on hCB1 and hCB2 with Ki values of 5.9 nM and 3.5 nM, respectively[1].
CB1/2 agonist 3 (compound 52) can partially induce [35S]GTPγS binding to hCB1-CHO cell membranes with an EC50 value of 30.99 nM, and slightly inhibit [35S]GTPγS binding to hCB2-CHO cell membranes with a mean EC50 value of 1.28 nM[1].
CB1/2 agonist 3 (compound 52) ((1 μM, 1 h) has antagonistic effect on CB1/CB2 agonist CP-55940 with a Kb value of 78.17 nM[1].

Reference

[1]. Antonella Brizzi, et al. Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity. Bioorg Med Chem. 2020 Jun 1;28(11):115513.
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