For research use only. Not for therapeutic Use.
CB1R Allosteric modulator 5, a selective cannabinoid-1 receptor (CB1R) inverse agonist with an IC50 value of 4.2 μM and EC50 value of ＞10 μM. CB1R Allosteric modulator 5 can be used for the research of metabolic and obesity[1].
CB1R Allosteric modulator 5 has cannabinoid-1 receptor (CB1R) activity with an IC50value of 4.2 μM and EC50 value of ＞10 μM[1].
| Catalog Number | I043345 |
| CAS Number | 334668-69-8 |
| Synonyms | cyclohexyl-[4-[3-(trifluoromethyl)phenyl]sulfonylpiperazin-1-yl]methanone |
| Molecular Formula | C18H23F3N2O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C18H23F3N2O3S/c19-18(20,21)15-7-4-8-16(13-15)27(25,26)23-11-9-22(10-12-23)17(24)14-5-2-1-3-6-14/h4,7-8,13-14H,1-3,5-6,9-12H2 |
| InChIKey | CRXJBISLCDTJDM-UHFFFAOYSA-N |
| SMILES | C1CCC(CC1)C(=O)N2CCN(CC2)S(=O)(=O)C3=CC=CC(=C3)C(F)(F)F |
| Reference | [1]. Petr Vachal, et al. 1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity. J Med Chem. 2009 Apr 23;52(8):2550-8 |
