CB5083

• CAT Number: I001945
• CAS Number: 1542705-92-9
• Molecular Formula: C₂₄H₂₃N₅O₂
• Molecular Weight: 413.47
• Purity: ≥95%
• Synonyms: 1-[7,8-dihydro-4-[(phenylmethyl)amino]-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methyl-1H-indole-4-carboxamide
• Target: p97
• Solubility: 10 mM in DMSO
• Storage: -20°C
• IC50: 11 nM
• IUPAC Name: 1-[4-(benzylamino)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidin-2-yl]-2-methylindole-4-carboxamide
• InChI: InChI=1S/C24H23N5O2/c1-15-12-18-17(22(25)30)8-5-9-21(18)29(15)24-27-20-10-11-31-14-19(20)23(28-24)26-13-16-6-3-2-4-7-16/h2-9,12H,10-11,13-14H2,1H3,(H2,25,30)(H,26,27,28)
• InChIKey: RDALZZCKQFLGJP-UHFFFAOYSA-N
• SMILES: CC1=CC2=C(C=CC=C2N1C3=NC4=C(COCC4)C(=N3)NCC5=CC=CC=C5)C(=O)N

CB5083（Cat No.:I001945）is a small molecule compound that has gained attention for its potential as an anticancer agent. It functions as a potent inhibitor of p97/VCP (valosin-containing protein), a AAA+ ATPase involved in various cellular processes, including protein quality control, endoplasmic reticulum-associated degradation, and DNA damage response. By inhibiting p97, CB5083 disrupts these processes, leading to the accumulation of misfolded proteins, cellular stress, and ultimately, cancer cell death. Preclinical studies have shown promise in enhancing the effectiveness of cancer treatments, with ongoing research focusing on its safety, pharmacokinetics, and clinical potential.