For research use only. Not for therapeutic Use.
CBL0100 is an inhibitor of viral transcriptional elongation, blocking both HIV-1 replication and reactivation.
| Catalog Number | I024214 |
| CAS Number | 1197996-83-0 |
| Synonyms | Curaxin 100; Curaxin100; Curaxin-100; CBL0100; CBL-0100; CBL 0100 |
| Molecular Formula | C24H26N2O2 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 6-(2-(Diethylamino)ethyl)-1,6,10,11-tetrahydro-3H-dicyclopenta[c,g]carbazole-3,9(2H)-dione |
| InChI | InChI=1S/C24H26N2O2/c1-3-25(4-2)13-14-26-19-9-5-15-17(7-11-21(15)27)23(19)24-18-8-12-22(28)16(18)6-10-20(24)26/h5-6,9-10H,3-4,7-8,11-14H2,1-2H3 |
| InChIKey | WBNDUJWRJNLCBD-UHFFFAOYSA-N |
| SMILES | O=C1CCC2=C1C=CC(N3CCN(CC)CC)=C2C4=C3C=CC5=C4CCC5=O |
| Reference | 1: Jean MJ, Hayashi T, Huang H, Brennan J, Simpson S, Purmal A, Gurova K, Keefer MC, Kobie JJ, Santoso NG, Zhu J. Curaxin CBL0100 Blocks HIV-1 Replication and Reactivation through Inhibition of Viral Transcriptional Elongation. Front Microbiol. 2017 Oct 17;8:2007. doi: 10.3389/fmicb.2017.02007. eCollection 2017. PubMed PMID: 29089933; PubMed Central PMCID: PMC5651003. |
