CBL0137

• CAT Number: I006313
• CAS Number: 1197996-80-7
• Molecular Formula: C21H24N2O2
• Molecular Weight: 336.43
• Purity: ≥95%
• Storage: 3 years -20°C powder
• SMILES: CC(C)NCCN1C2=C(C=C(C=C2)C(=O)C)C3=C1C=CC(=C3)C(=O)C

CBL0137 (Curaxin-137) is an inhibitor of the histone chaperone FACT (facilitates chromatin transcription) that simultaneously suppresses NF-κB and activates p53 with EC50 of 0.47 μM and 0.37 μM, respectively.

Reference

[1] Alexander V Gasparian, et al. Sci Transl Med. 2011 Aug 10;3(95):95ra74.