For research use only. Not for therapeutic Use.
CBP/p300-IN-10 is a highly potent histone acetyltransferase EP300 and CREBBP with IC50 values of 26 nM and 39 nM, respectively. CBP/p300-IN-10 can be used to research anticancer[1].
CBP/p300-IN-10 (example 84) (0-1 μM; 3 h) inhibit H3K27Ac activity in LK2 cells with an IC50 of 22 nM[1].
CBP/p300-IN-10 (38 nM-10 mM; 3 days) has inhibitory activity against LK2 and TE-8[1].
| Catalog Number | I042667 |
| CAS Number | 2259641-71-7 |
| Synonyms | (2R,4R)-1-[1-[4-(difluoromethoxy)phenyl]-4,4-difluorocyclohexanecarbonyl]-4-fluoro-N-(1H-pyrazolo[4,3-b]pyridin-5-yl)pyrrolidine-2-carboxamide |
| Molecular Formula | C25H24F5N5O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C25H24F5N5O3/c26-15-11-19(21(36)33-20-6-5-17-18(32-20)12-31-34-17)35(13-15)22(37)24(7-9-25(29,30)10-8-24)14-1-3-16(4-2-14)38-23(27)28/h1-6,12,15,19,23H,7-11,13H2,(H,31,34)(H,32,33,36)/t15-,19-/m1/s1 |
| InChIKey | IGBIPTRCWSVZCO-DNVCBOLYSA-N |
| SMILES | C1CC(CCC1(C2=CC=C(C=C2)OC(F)F)C(=O)N3CC(CC3C(=O)NC4=NC5=C(C=C4)NN=C5)F)(F)F |
| Reference | [1]. Naito, Hiroyuki, et al. Preparation of amino acid amide derivatives such as L- and D-prolinamide derivatives as Ep300/CREBBP inhibitors. WO2018235966A1 |
