For research use only. Not for therapeutic Use.
CBP/p300-IN-8 is a potent inhibitor of the CBP/P300 family of bromodomains. CBP/p300-IN-8 inhibits CBP (IC50=0.01-0.1 µΜ) and BRD4 (IC50=1-1000 µΜ) activity[1].
| Catalog Number | I044692 |
| CAS Number | 2304416-91-7 |
| Synonyms | (1S,3S)-3-[(7S)-2-benzyl-6-methoxycarbonyl-7-methyl-8,9-dihydro-7H-imidazo[4,5-f]quinolin-3-yl]cyclohexane-1-carboxylic acid |
| Molecular Formula | C27H31N3O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C27H31N3O4/c1-17-11-12-21-22(29(17)27(33)34-2)13-14-23-25(21)28-24(15-18-7-4-3-5-8-18)30(23)20-10-6-9-19(16-20)26(31)32/h3-5,7-8,13-14,17,19-20H,6,9-12,15-16H2,1-2H3,(H,31,32)/t17-,19-,20-/m0/s1 |
| InChIKey | ABNLUJMIBRFYRV-IHPCNDPISA-N |
| SMILES | CC1CCC2=C(N1C(=O)OC)C=CC3=C2N=C(N3C4CCCC(C4)C(=O)O)CC5=CC=CC=C5 |
| Reference | [1]. Shawn E.R. Schiller, et al. Tetrahydro-imidazo quinoline compositions as cbp/p300 inhibitors. WO2019055877A1. |
