Cbz-NH-PEG1-CH2CH2COOH

• CAT Number: I016183
• CAS Number: 1205751-19-4
• Molecular Formula: C₁₃H₁₇NO₅
• Molecular Weight: 267.28
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: 3-[2-(phenylmethoxycarbonylamino)ethoxy]propanoic acid
• InChI: InChI=1S/C13H17NO5/c15-12(16)6-8-18-9-7-14-13(17)19-10-11-4-2-1-3-5-11/h1-5H,6-10H2,(H,14,17)(H,15,16)
• InChIKey: CRNWVZCUBIJZEC-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)COC(=O)NCCOCCC(=O)O

Cbz-NH-PEG1-CH2CH2COOH is a PEG-based PROTAC linker commonly employed in the synthesis of PROTACs (proteolysis-targeting chimeras). It consists of a carbobenzyloxy (Cbz) group, a PEG spacer with one ethylene glycol unit (PEG1), and a carboxylic acid (CH2CH2COOH) at the end. This linker provides stability, flexibility, and hydrophilicity to the PROTAC molecule. It allows for the conjugation of different ligands to target proteins of interest and facilitates the recruitment of E3 ligases for targeted protein degradation. The incorporation of this linker in PROTAC synthesis contributes to the development of novel therapeutic strategies.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.