Cbz-NH-PEG3-C2-acid

• CAT Number: I015961
• CAS Number: 1310327-18-4
• Molecular Formula: C₁₇H₂₅NO₇
• Molecular Weight: 355.38
• Purity: ≥95%
• Target: PROTAC Linkers

Cbz-NH-PEG3-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562