Cbz-NH-PEG3-C2-acid

• CAT Number: I015961
• CAS Number: 1310327-18-4
• Molecular Formula: C₁₇H₂₅NO₇
• Molecular Weight: 355.38
• Purity: ≥95%
• Target: PROTAC Linkers
• IUPAC Name: 3-[2-[2-[2-(phenylmethoxycarbonylamino)ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C17H25NO7/c19-16(20)6-8-22-10-12-24-13-11-23-9-7-18-17(21)25-14-15-4-2-1-3-5-15/h1-5H,6-14H2,(H,18,21)(H,19,20)
• InChIKey: SBHUTZVKPJPFBD-UHFFFAOYSA-N
• SMILES: C1=CC=C(C=C1)COC(=O)NCCOCCOCCOCCC(=O)O

Cbz-NH-PEG3-C2-acid（Cat No.:I015961）is a compound that features a carbobenzyloxy (Cbz) protective group on an amine, a polyethylene glycol (PEG) chain with three ethylene glycol units, and a carboxylic acid group attached to an ethyl spacer (C2). This structure combines the benefits of PEGylation, such as enhanced solubility and stability, with the functional versatility provided by the amine and carboxyl groups. The Cbz group can be removed under mild conditions to expose the free amine for further conjugation or modification. Cbz-NH-PEG3-C2-acid is used in drug delivery, peptide conjugation, and biomolecular research.

Reference

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562